Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
adhAlcohol dehydrogenase I, putative. (336 aa)    
Predicted Functional Partners:
ABD29294.1
Alcohol dehydrogenase, iron-containing, putative; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
 0.989
aldA
Aldehyde dehydrogenase, putative.
   
 0.929
ABD31394.1
Aldehyde dehydrogenase, putative.
   
  0.910
ABD29269.1
3-ketoacyl-acyl carrier protein reductase, putative.
  
 
   0.584
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
    
 
 0.580
ABD29747.1
Conserved hypothetical protein.
       0.563
aldH1
Aldehyde dehydrogenase, putative; Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the oxidation of 4,4'- diaponeurosporen-4-al to yield 4,4'-diaponeurosporenoic acid. Belongs to the aldehyde dehydrogenase family.
   
  0.553
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
      
 0.505
pflB
Formate acetyltransferase; Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
   
  
 0.484
pyk
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
  
 0.477
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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