Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ABD29801.1ABC transporter permease, putative. (629 aa)    
Predicted Functional Partners:
ABD29800.1
ABC transporter ATP-binding protein, putative.
 
 0.997
graS
Conserved hypothetical protein; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Functions as a sensor protein kinase which phosphorylates GraR through the auxiliary protein GraX. In turn, GraR up-regulates many genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. Confers resistance to vancomycin, polymyxin B, lysozyme and LL-37.
 
 
 0.994
ABD32021.1
ABC transporter, ATP-binding protein, putative.
 
 
 0.896
graR
Conserved hypothetical protein; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Upon phosphorylation by GraS, functions as a transcription regulator by direct binding to promoter regions of target genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis.
     0.874
ABD31946.1
Sensor histidine kinase, putative.
 
 
 
 0.845
ABD31945.1
ABC transporter, ATP-binding protein, putative.
  
   0.728
ABD31947.1
DNA-binding response regulator, putative.
  
     0.696
ABD29457.1
ABC transporter, ATP-binding protein, putative.
   
   0.554
ABD30095.1
ABC transporter, ATP-binding protein, putative.
   
   0.554
hrtA
Conserved hypothetical protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity).
   
   0.554
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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