STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABD29804.1Secretory antigen SsaA-like protein; Has weak lytic activity toward S.aureus cells. (265 aa)    
Predicted Functional Partners:
guaA
GMP synthase, putative; Catalyzes the synthesis of GMP from XMP.
    
 0.698
ABD31195.1
Conserved hypothetical protein.
    
   0.505
ABD29805.1
Conserved hypothetical protein.
       0.469
ABD30255.1
Penicillin-binding protein 1.
   
 0.468
spa
Protein A; Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteoge [...]
  
 
 0.458
ABD31960.1
Aureolysin, putative; Extracellular zinc metalloprotease.
  
 
 
 0.423
ABD29921.1
Conserved hypothetical protein.
   
 
 0.421
ABD31229.1
Phi PVL orf 13-like protein.
   
 
 0.421
lytN
Cell wall hydrolase, putative; Probably involved in peptidoglycan hydrolysis.
  
     0.418
traP
Conserved hypothetical protein; Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation.
      
 0.412
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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