STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnrRibonuclease R, putative; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (790 aa)    
Predicted Functional Partners:
smpB
SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
  
  
 0.930
ABD29930.1
Carboxylesterase precursor, putative.
  
    0.880
ABD29929.1
Preprotein translocase, SecG subunit; Subunit of the protein translocation channel SecYEG (By similarity). While not essential, it considerably increases the export efficiency of extracellular proteins; Belongs to the SecG family.
  
  
 0.762
dnaK
DNAk protein, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 
 0.755
rny
Conserved hypothetical protein; Endoribonuclease that initiates mRNA decay (By similarity). In vitro, catalyzes the hydrolysis of both 2',3'-cyclic AMP and 2',3'- cyclic GMP into 3'-AMP and 3'-GMP, respectively, at the 3'-terminal of RNA. Activates sarZ and agr operon resulting in the expression of virulence genes such as hemolysin, DNase and protease. Contributes to virulence in both silkworm-infection model and mice.
     
 0.753
pnp
Polyribonucleotide nucleotidyltransferase, putative; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
   
  
 0.742
rsmA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
   
 
 0.723
cshA
ATP-dependent RNA helicase, DEAD box family, putative; A probable ATP-dependent RNA helicase with RNA-dependent ATPase activity. Involved in regulation of biofilm formation and hemolysis via its effects on stability of mRNA from the agrBDCA operon. Also involved in response to cold stress.
   
 
 0.702
hfq
Host factor 1 protein, putative; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.
 
 
 
 0.698
ABD29928.1
Conserved hypothetical protein.
       0.691
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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