STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdrCoenzyme A disulfide reductase, putative; Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide. Is also active with other disulfide substrates containing at least one 4'-phosphopantethienyl moiety such as 4,4'- diphosphopantethine, but is not able to reduce oxidized glutathione, cystine, pantethine, or H(2)O(2); Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family. (438 aa)    
Predicted Functional Partners:
ABD29224.1
Conserved hypothetical protein; Belongs to the sulfur carrier protein TusA family.
  
 0.983
ABD30034.1
Conserved hypothetical protein.
       0.763
ABD31691.1
Assimilatory nitrite reductase [NAD(P)H], small subunit, putative.
  
 
 0.674
ABD30035.1
Conserved hypothetical protein.
       0.651
tpx
Conserved hypothetical protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
      
 0.623
ABD31593.1
Formate dehydrogenase, alpha subunit, putative; In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
      0.588
ABD29287.1
Conserved hypothetical protein.
    
 
 0.559
sodA
Superoxide dismutase, Mn, putative; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in maintaining cell viability throughout all stages of growth, but may be the major SOD activity in the exponential growth- phase. Has a role in resisting external superoxide stress. Involved in acid tolerance and the acid-adaptive response. Mediates the derepression of perR regulon in the response to HOCl stress when the level of SOD activity is low.
  
 
 0.531
spxA
Conserved hypothetical protein; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily.
      
 0.496
ABD29294.1
Alcohol dehydrogenase, iron-containing, putative; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
 
  
 0.487
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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