node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABD29214.1 | ABD29985.1 | SAOUHSC_00025 | SAOUHSC_00860 | Conserved hypothetical protein. | 5-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | 0.687 |
ABD29214.1 | ABD30221.1 | SAOUHSC_00025 | SAOUHSC_01107 | Conserved hypothetical protein. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.886 |
ABD29214.1 | guaA | SAOUHSC_00025 | SAOUHSC_00375 | Conserved hypothetical protein. | GMP synthase, putative; Catalyzes the synthesis of GMP from XMP. | 0.899 |
ABD29214.1 | guaB | SAOUHSC_00025 | SAOUHSC_00374 | Conserved hypothetical protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.889 |
ABD29214.1 | purA | SAOUHSC_00025 | SAOUHSC_00019 | Conserved hypothetical protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.888 |
ABD29638.1 | ABD30221.1 | SAOUHSC_00485 | SAOUHSC_01107 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.888 |
ABD29638.1 | guaA | SAOUHSC_00485 | SAOUHSC_00375 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | GMP synthase, putative; Catalyzes the synthesis of GMP from XMP. | 0.947 |
ABD29638.1 | guaB | SAOUHSC_00485 | SAOUHSC_00374 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.932 |
ABD29638.1 | ndk | SAOUHSC_00485 | SAOUHSC_01485 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Nucleoside diphosphate kinase, putative; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.523 |
ABD29638.1 | purA | SAOUHSC_00485 | SAOUHSC_00019 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.943 |
ABD29638.1 | xpt | SAOUHSC_00485 | SAOUHSC_00372 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.941 |
ABD29985.1 | ABD29214.1 | SAOUHSC_00860 | SAOUHSC_00025 | 5-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Conserved hypothetical protein. | 0.687 |
ABD29985.1 | ABD30221.1 | SAOUHSC_00860 | SAOUHSC_01107 | 5-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.729 |
ABD29985.1 | guaA | SAOUHSC_00860 | SAOUHSC_00375 | 5-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | GMP synthase, putative; Catalyzes the synthesis of GMP from XMP. | 0.760 |
ABD29985.1 | guaB | SAOUHSC_00860 | SAOUHSC_00374 | 5-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.736 |
ABD29985.1 | purA | SAOUHSC_00860 | SAOUHSC_00019 | 5-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.734 |
ABD30221.1 | ABD29214.1 | SAOUHSC_01107 | SAOUHSC_00025 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Conserved hypothetical protein. | 0.886 |
ABD30221.1 | ABD29638.1 | SAOUHSC_01107 | SAOUHSC_00485 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.888 |
ABD30221.1 | ABD29985.1 | SAOUHSC_01107 | SAOUHSC_00860 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | 0.729 |
ABD30221.1 | ABD30222.1 | SAOUHSC_01107 | SAOUHSC_01108 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Conserved hypothetical protein. | 0.972 |