Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family.

Conserved hypothetical protein; Secreted protein that plays a role in the inhibition of host innate immune system. Modulates the interaction between host SELPLG and P-selectin thereby preventing initial rolling of neutrophils toward the site of infection. Interferes with leukocyte trafficking by inhibiting host metalloproteinase-9/MMP9 activity. Associates also with two different platelet surface receptors GP1A and GP6 leading to platelet activation and aggregation. Belongs to the staphylococcal/streptococcal toxin family.

Conserved hypothetical protein; Plays a role in the inhibition of host complement activation via the classical pathway by interacting with the Fc region of human IgG and thereby interfering with the IgG/C1q interaction. Inhibits also the penultimate step of plasma clotting by interacting with prothrombin/F2 and coagulation factor X/F12. Does not affect the protease activity of thrombin but interferes with the conversion of prothrombin to thrombin. Interacts with human receptor CXCR4 and specifically inhibits CXCL12-induced calcium mobilization and cell migration.

Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses; Belongs to the SCIN family.

Conserved hypothetical protein; Secreted protein that plays an essential role in immune innate response inhibition by interacting with and inhibiting host TLR2. In turn, bacteria recognition by immune cells is impaired and cytokine production is inhibited. Mechanistically, by interacting with TLR2, blocks ligand binding and thus inhibits activation. Second, by interacting with an already formed TLR2-lipopeptide complex, prevents TLR heterodimerization and downstream signaling. The interaction with host TLR2 does not involve sialyl Lewis X interactions. Belongs to the staphylococcal/str [...]

Conserved hypothetical protein; Plays a role in the inhibition of host complement-mediated lysis and serum bactericidal activity by interacting with complement component C5. Affects all three pathways of complement activation and inhibits the cleavage of C5 by preventing its binding to C5 convertases. In turn, prevents C5a-mediated neutrophil migration.

Conserved hypothetical protein; Mediates virulence by proteolytically cleaving host proteins, including collagens types I and IV as well as human cytokines IL8, IL17A, and IFN-gamma.