STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rnj2Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and endonuclease activity, with the exonuclease activity probably being most important in vivo. Involved in maturation of 16S rRNA, rnpB (the RNA component of RNase P) maturation and degradation, and mRNA maturation and/or decay. This subunit probably plays a structural rather than enzymatic role as mutation of its putative active site gives no phenotype, and its deletion is partially complemented by inactive RNase J1. (523 aa)    
Predicted Functional Partners:
rny
Conserved hypothetical protein; Endoribonuclease that initiates mRNA decay (By similarity). In vitro, catalyzes the hydrolysis of both 2',3'-cyclic AMP and 2',3'- cyclic GMP into 3'-AMP and 3'-GMP, respectively, at the 3'-terminal of RNA. Activates sarZ and agr operon resulting in the expression of virulence genes such as hemolysin, DNase and protease. Contributes to virulence in both silkworm-infection model and mice.
  
 
 0.975
rnj1
Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and endonuclease activity, with the exonuclease activity probably being most important in vivo. Involved in maturation of 16S rRNA, rnpB (the RNA component of RNase P) maturation and degradation, and mRNA maturation and/or decay. This subunit has the exonuclease activity.
  
  
0.939
pnp
Polyribonucleotide nucleotidyltransferase, putative; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
 
  
 0.928
cshA
ATP-dependent RNA helicase, DEAD box family, putative; A probable ATP-dependent RNA helicase with RNA-dependent ATPase activity. Involved in regulation of biofilm formation and hemolysis via its effects on stability of mRNA from the agrBDCA operon. Also involved in response to cold stress.
   
  
 0.753
ABD30354.1
Conserved hypothetical protein; Belongs to the FtsK/SpoIIIE/SftA family.
  
    0.686
ABD30355.1
Conserved hypothetical protein.
       0.684
rnpA
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
    
 
 0.683
ABD30357.1
Conserved hypothetical protein.
  
    0.668
ABD30356.1
Conserved hypothetical protein.
  
    0.667
ABD30358.1
Conserved hypothetical protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
       0.666
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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