STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABD30519.1Conserved hypothetical protein; Belongs to the peptidase S41A family. (496 aa)    
Predicted Functional Partners:
murG
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.
 
    0.725
ABD30518.1
Conserved hypothetical protein.
     
 0.683
msrB
Methionine sulfoxide reductase, putative; Belongs to the MsrB Met sulfoxide reductase family.
      0.649
ABD31078.1
Phage tail fiber protein, putative.
   
   0.605
ABD31433.1
Conserved hypothetical protein.
   
   0.605
ABD31805.1
Fibronectin binding protein B, putative.
   
   0.605
fnbA
Fibronectin-binding protein precursor, putative; Possesses multiple, substituting fibronectin (Fn) binding regions, each capable of conferring adherence to both soluble and immobilized forms of Fn. This confers to S.aureus the ability to invade endothelial cells both in vivo and in vitro, without requiring additional factors, although in a slow and inefficient way through actin rearrangements in host cells. This invasion process is mediated by integrin alpha-5/beta-1. Promotes bacterial attachment to both soluble and immobilized forms of fibrinogen (Fg) by means of a unique binding sit [...]
   
   0.605
sraP
Conserved hypothetical protein; Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection. Plays a positive role in biofilm formation, possibly by self-association via the non-repeat region (NRR or binding region, BR). Binds to and plays a role in human lung epithelial cell invasion via the L-lectin module of its NRR domain; N-acetylneuraminic acid (Neu5Ac) inhibits binding. Treatment of host cells with neuraminidase decreases adherence of S.aureus cells, suggesting SraP recognizes a host terminal N [...]
   
   0.605
msrA2
Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
 
    0.583
ABD30520.1
Hypothetical protein.
       0.572
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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