STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (261 aa)    
Predicted Functional Partners:
ABD30949.1
Conserved hypothetical protein.
   
 0.925
rocA
Delta-1-pyrroline-5-carboxylate dehydrogenase, putative; Belongs to the aldehyde dehydrogenase family. RocA subfamily.
   
 
 0.914
sbnB
Ornithine cyclodeaminase, putative; Catalyzes the hydrolysis of N-((2S)-2-amino-2-carboxyethyl)- L-glutamate (ACEGA) to form L-2,3-diaminopropionic acid and 2- oxoglutarate. Involved in the biosynthesis of L-2,3-diaminopropionic acid (L-Dap), a precursor of staphyloferrin B and antibiotics. Belongs to the ornithine cyclodeaminase/mu-crystallin family.
   
 
 0.913
ABD30675.1
Conserved hypothetical protein.
       0.740
hisF
Imidazole glycerol phosphate synthase subunit hisF, putative; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit; In the C-terminal section; belongs to the PRA-PH family.
     
 0.680
pyk
Pyruvate kinase; Belongs to the pyruvate kinase family.
     
 0.628
rocD-2
Ornithine aminotransferase, putative; Catalyzes the interconversion of ornithine to glutamate semialdehyde.
  
  
 0.610
rocD
Ornithine aminotransferase, putative; Catalyzes the interconversion of ornithine to glutamate semialdehyde.
  
  
 0.608
ABD29594.1
Glutamate synthase, large subunit, putative.
     
 0.537
guaA
GMP synthase, putative; Catalyzes the synthesis of GMP from XMP.
     
 0.529
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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