node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABD29324.1 | dltA | SAOUHSC_00144 | SAOUHSC_00869 | Conserved hypothetical protein; Belongs to the ATP-dependent AMP-binding enzyme family. | D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] | 0.959 |
ABD29324.1 | engB | SAOUHSC_00144 | SAOUHSC_01777 | Conserved hypothetical protein; Belongs to the ATP-dependent AMP-binding enzyme family. | GTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | 0.731 |
ABD29324.1 | hemA | SAOUHSC_00144 | SAOUHSC_01776 | Conserved hypothetical protein; Belongs to the ATP-dependent AMP-binding enzyme family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.613 |
ABD29324.1 | hemB | SAOUHSC_00144 | SAOUHSC_01772 | Conserved hypothetical protein; Belongs to the ATP-dependent AMP-binding enzyme family. | Porphobilinogen synthase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.557 |
ABD29324.1 | hemL1 | SAOUHSC_00144 | SAOUHSC_01771 | Conserved hypothetical protein; Belongs to the ATP-dependent AMP-binding enzyme family. | Glutamate-1-semialdehyde-2,1-aminomutase. | 0.932 |
ABD29324.1 | hemL2 | SAOUHSC_00144 | SAOUHSC_02000 | Conserved hypothetical protein; Belongs to the ATP-dependent AMP-binding enzyme family. | Glutamate-1-semialdehyde-2,1-aminomutase, putative. | 0.927 |
ABD30842.1 | ABD30844.1 | SAOUHSC_01773 | SAOUHSC_01775 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Conserved hypothetical protein. | 0.916 |
ABD30842.1 | ABD31690.1 | SAOUHSC_01773 | SAOUHSC_02682 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrin-III C-methyltransferase, putative; Belongs to the precorrin methyltransferase family. | 0.995 |
ABD30842.1 | engB | SAOUHSC_01773 | SAOUHSC_01777 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | GTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | 0.637 |
ABD30842.1 | hemA | SAOUHSC_01773 | SAOUHSC_01776 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.964 |
ABD30842.1 | hemB | SAOUHSC_01773 | SAOUHSC_01772 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.993 |
ABD30842.1 | hemC | SAOUHSC_01773 | SAOUHSC_01774 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
ABD30842.1 | hemL1 | SAOUHSC_01773 | SAOUHSC_01771 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde-2,1-aminomutase. | 0.961 |
ABD30842.1 | hemL2 | SAOUHSC_01773 | SAOUHSC_02000 | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Glutamate-1-semialdehyde-2,1-aminomutase, putative. | 0.812 |
ABD30844.1 | ABD30842.1 | SAOUHSC_01775 | SAOUHSC_01773 | Conserved hypothetical protein. | uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.916 |
ABD30844.1 | ABD31690.1 | SAOUHSC_01775 | SAOUHSC_02682 | Conserved hypothetical protein. | uroporphyrin-III C-methyltransferase, putative; Belongs to the precorrin methyltransferase family. | 0.440 |
ABD30844.1 | engB | SAOUHSC_01775 | SAOUHSC_01777 | Conserved hypothetical protein. | GTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | 0.694 |
ABD30844.1 | hemA | SAOUHSC_01775 | SAOUHSC_01776 | Conserved hypothetical protein. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.908 |
ABD30844.1 | hemB | SAOUHSC_01775 | SAOUHSC_01772 | Conserved hypothetical protein. | Porphobilinogen synthase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.842 |
ABD30844.1 | hemC | SAOUHSC_01775 | SAOUHSC_01774 | Conserved hypothetical protein. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.881 |