STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfkA6-phosphofructokinase, putative; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (307 aa)    
Predicted Functional Partners:
pyk
Pyruvate kinase; Belongs to the pyruvate kinase family.
 
 
 0.999
pgi
Glucose-6-phosphate isomerase.
  
 0.995
guaA
GMP synthase, putative; Catalyzes the synthesis of GMP from XMP.
   
  
 0.979
ABD31397.1
Conserved hypothetical protein.
 
 
 0.970
fda
Fructose-bisphosphate aldolase class-I, putative.
  
 0.968
fbp
Conserved hypothetical protein.
     
 0.957
rny
Conserved hypothetical protein; Endoribonuclease that initiates mRNA decay (By similarity). In vitro, catalyzes the hydrolysis of both 2',3'-cyclic AMP and 2',3'- cyclic GMP into 3'-AMP and 3'-GMP, respectively, at the 3'-terminal of RNA. Activates sarZ and agr operon resulting in the expression of virulence genes such as hemolysin, DNase and protease. Contributes to virulence in both silkworm-infection model and mice.
  
 
 0.928
ABD30964.1
Conserved hypothetical protein.
  
 
 0.924
lacC
Tagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
     
 0.922
ABD30434.1
Transketolase; Belongs to the transketolase family.
  
 
 0.920
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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