| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| hlgB | hlgC | SAOUHSC_02710 | SAOUHSC_02709 | Leukocidin f subunit precursor; Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity). Belongs to the aerolysin family. | Leukocidin s subunit precursor, putative; Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity). Belongs to the aerolysin family. | 0.998 |
| hlgB | lip2 | SAOUHSC_02710 | SAOUHSC_00300 | Leukocidin f subunit precursor; Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity). Belongs to the aerolysin family. | Lipase precursor. | 0.414 |
| hlgB | splA | SAOUHSC_02710 | SAOUHSC_01942 | Leukocidin f subunit precursor; Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity). Belongs to the aerolysin family. | Serine protease SplA. | 0.467 |
| hlgB | splB | SAOUHSC_02710 | SAOUHSC_01941 | Leukocidin f subunit precursor; Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity). Belongs to the aerolysin family. | Serine protease SplB; Serine protease that cleaves specifically after the sequence Trp-Glu-Leu-Gln; Belongs to the peptidase S1B family. | 0.499 |
| hlgC | hlgB | SAOUHSC_02709 | SAOUHSC_02710 | Leukocidin s subunit precursor, putative; Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity). Belongs to the aerolysin family. | Leukocidin f subunit precursor; Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity). Belongs to the aerolysin family. | 0.998 |
| hlgC | splA | SAOUHSC_02709 | SAOUHSC_01942 | Leukocidin s subunit precursor, putative; Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity). Belongs to the aerolysin family. | Serine protease SplA. | 0.474 |
| hlgC | splB | SAOUHSC_02709 | SAOUHSC_01941 | Leukocidin s subunit precursor, putative; Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity). Belongs to the aerolysin family. | Serine protease SplB; Serine protease that cleaves specifically after the sequence Trp-Glu-Leu-Gln; Belongs to the peptidase S1B family. | 0.500 |
| hly | hysA | SAOUHSC_01121 | SAOUHSC_02463 | Alpha-hemolysin precursor; Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity (By similarity). Belongs to the aerolysin family. | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | 0.458 |
| hly | lip2 | SAOUHSC_01121 | SAOUHSC_00300 | Alpha-hemolysin precursor; Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity (By similarity). Belongs to the aerolysin family. | Lipase precursor. | 0.475 |
| hly | splA | SAOUHSC_01121 | SAOUHSC_01942 | Alpha-hemolysin precursor; Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity (By similarity). Belongs to the aerolysin family. | Serine protease SplA. | 0.471 |
| hly | splB | SAOUHSC_01121 | SAOUHSC_01941 | Alpha-hemolysin precursor; Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity (By similarity). Belongs to the aerolysin family. | Serine protease SplB; Serine protease that cleaves specifically after the sequence Trp-Glu-Leu-Gln; Belongs to the peptidase S1B family. | 0.414 |
| hly | sspB | SAOUHSC_01121 | SAOUHSC_00987 | Alpha-hemolysin precursor; Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity (By similarity). Belongs to the aerolysin family. | Cysteine protease precursor, putative; Cysteine protease that plays an important role in the inhibition of host innate immune response. Degrades host elastin, fibrogen, fibronectin and kininogen. Blocks phagocytosis of opsonised S. aureus by neutrophils and monocytes by inducing their death in a proteolytic activity-dependent manner. Decreases surface expression of the 'don't eat me' signal CD31 on neutrophils. Cleaves host galectin- 3/LGALS3, thereby inhibiting the neutrophil-activating ability of the lectin. | 0.521 |
| hysA | hly | SAOUHSC_02463 | SAOUHSC_01121 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | Alpha-hemolysin precursor; Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity (By similarity). Belongs to the aerolysin family. | 0.458 |
| hysA | lip2 | SAOUHSC_02463 | SAOUHSC_00300 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | Lipase precursor. | 0.464 |
| hysA | splA | SAOUHSC_02463 | SAOUHSC_01942 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | Serine protease SplA. | 0.418 |
| hysA | splB | SAOUHSC_02463 | SAOUHSC_01941 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | Serine protease SplB; Serine protease that cleaves specifically after the sequence Trp-Glu-Leu-Gln; Belongs to the peptidase S1B family. | 0.405 |
| hysA | splC | SAOUHSC_02463 | SAOUHSC_01939 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | Serine protease SplC. | 0.438 |
| hysA | sspB | SAOUHSC_02463 | SAOUHSC_00987 | Hyaluronate lyase; Belongs to the polysaccharide lyase 8 family. | Cysteine protease precursor, putative; Cysteine protease that plays an important role in the inhibition of host innate immune response. Degrades host elastin, fibrogen, fibronectin and kininogen. Blocks phagocytosis of opsonised S. aureus by neutrophils and monocytes by inducing their death in a proteolytic activity-dependent manner. Decreases surface expression of the 'don't eat me' signal CD31 on neutrophils. Cleaves host galectin- 3/LGALS3, thereby inhibiting the neutrophil-activating ability of the lectin. | 0.441 |
| lip2 | hlgB | SAOUHSC_00300 | SAOUHSC_02710 | Lipase precursor. | Leukocidin f subunit precursor; Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity). Belongs to the aerolysin family. | 0.414 |
| lip2 | hly | SAOUHSC_00300 | SAOUHSC_01121 | Lipase precursor. | Alpha-hemolysin precursor; Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity (By similarity). Belongs to the aerolysin family. | 0.475 |
