STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABD31040.1Sensor histidine kinase, putative. (370 aa)    
Predicted Functional Partners:
ABD31039.1
DNA-binding response regulator, putative.
 
 0.994
nreC
Conserved hypothetical protein; Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. Phosphorylated NreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT, and activates their expression (By similarity).
 
 0.970
vraR
DNA-binding response regulator VraR, putative; Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis. Upon cellular stress, the histidine kinase VraS transfers the phosphoryl group onto VraR. Upon phosphorylation, VraR dimerizes at the N-terminal domain. In turn, phosphorylation-induced dimerization expand and enhance the VraR binding to its own promoter leading to increased expression and subsequent modulation of as many as 40 genes, which ultimately constitute the S.aureus response to cell wall damage. In addition, [...]
 
 0.969
ABD30412.1
Conserved hypothetical protein.
 
 0.968
ABD31041.1
Ribosomal large subunit pseudouridine synthase, RluD subfamily, putative.
 
     0.774
kdpD
Sensor protein KdpD, putative; Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations. Regulates also capsular polysaccharide production. May function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals. In turn, KpdE functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh.
    
 0.724
hptR
Response regulator receiver domain protein; Member of the two-component regulatory system HptS/HptR that regulates genes involved in hexose phosphate transport system in response to changes in extracellular phosphate sources. Activates uhpT expression to facilitate glucose-6- phosphate/G6P utilization by directly binding to its promoter. Antagonizes CcpA-dependent transcription of a subset of CcpA-regulated genes involved in antibiotic susceptibility.
 
  
  0.721
guaA
GMP synthase, putative; Catalyzes the synthesis of GMP from XMP.
  
 
  0.675
ribBA
Riboflavin biosynthesis protein, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
    
  0.626
leuS
leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
   0.605
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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