Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ABD31078.1Phage tail fiber protein, putative. (390 aa)    
Predicted Functional Partners:
ABD31083.1
phiETA ORF57-like protein.
   
   0.877
ABD31084.1
Phi ETA orf 56-like protein.
   
   0.877
ABD31086.1
Conserved hypothetical phage protein.
  
   0.876
ABD31085.1
Phi ETA orf 55-like protein.
   
   0.874
ABD31090.1
Phage structural protein, putative.
   
   0.850
ABD31079.1
Bifunctional autolysin precursor.
       0.776
ABD31077.1
Phi ETA orf 63-like protein.
       0.774
spa
Protein A; Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteoge [...]
  
 
 0.702
lytO
Autolysin; Has weak lytic activity toward S.aureus cells. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
       0.605
ABD31076.1
Holin.
       0.605
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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