Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ABD31079.1Bifunctional autolysin precursor. (632 aa)    
Predicted Functional Partners:
ABD31078.1
Phage tail fiber protein, putative.
       0.776
ABD31077.1
Phi ETA orf 63-like protein.
       0.757
ABD31076.1
Holin.
       0.613
ABD31087.1
Phage tape measure protein.
     
 0.612
lytO
Autolysin; Has weak lytic activity toward S.aureus cells. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
      
0.593
spa
Protein A; Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteoge [...]
  
  
 0.566
ABD31085.1
Phi ETA orf 55-like protein.
 
   
 0.564
isaA
Immunodominant antigen A, putative; Is able to cleave peptidoglycan. Belongs to the transglycosylase family. IsaA subfamily.
  
  
 0.563
ABD30827.1
Conserved hypothetical protein.
  
     0.560
sceD
sceD protein, putative; Is able to cleave peptidoglycan and affects clumping and separation of bacterial cells. Is required for normal growth under stressful conditions. Is essential for nasal colonization. Belongs to the transglycosylase family. SceD subfamily.
  
  
 0.545
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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