node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABD31156.1 | ABD31157.1 | SAOUHSC_02106 | SAOUHSC_02107 | Conserved hypothetical protein. | UDP-N-acetylmuramyl tripeptide synthetase, putative. | 0.999 |
ABD31156.1 | ftnA | SAOUHSC_02106 | SAOUHSC_02108 | Conserved hypothetical protein. | Ferritin, putative; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. | 0.695 |
ABD31157.1 | ABD31156.1 | SAOUHSC_02107 | SAOUHSC_02106 | UDP-N-acetylmuramyl tripeptide synthetase, putative. | Conserved hypothetical protein. | 0.999 |
ABD31157.1 | ftnA | SAOUHSC_02107 | SAOUHSC_02108 | UDP-N-acetylmuramyl tripeptide synthetase, putative. | Ferritin, putative; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. | 0.695 |
ABD31157.1 | hisF | SAOUHSC_02107 | SAOUHSC_03008 | UDP-N-acetylmuramyl tripeptide synthetase, putative. | Imidazole glycerol phosphate synthase subunit hisF, putative; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit; In the C-terminal section; belongs to the PRA-PH family. | 0.451 |
ahpC | ftnA | SAOUHSC_00365 | SAOUHSC_02108 | Alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Is important for survival under desiccation conditions. Not required for virulence although is necessary for nasal colonization. | Ferritin, putative; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. | 0.703 |
ahpC | perR | SAOUHSC_00365 | SAOUHSC_01997 | Alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Is important for survival under desiccation conditions. Not required for virulence although is necessary for nasal colonization. | Ferric uptake regulator-like protein, putative; Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. Regulates expression of genes encoding antioxidant proteins, such as katA, ahpCF, bcp and trxB. Also regulates expression of the iron-storage protein ftn, the ferritin-like protein mrgA, the ferric uptake regulator fur, the manganese transporter operon mntABC, and its own expression. May act as a hydrogen peroxide and organic hydroperoxide sensor. Required for full virulence in a murine skin abscess model of infection. | 0.735 |
ftnA | ABD31156.1 | SAOUHSC_02108 | SAOUHSC_02106 | Ferritin, putative; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. | Conserved hypothetical protein. | 0.695 |
ftnA | ABD31157.1 | SAOUHSC_02108 | SAOUHSC_02107 | Ferritin, putative; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. | UDP-N-acetylmuramyl tripeptide synthetase, putative. | 0.695 |
ftnA | ahpC | SAOUHSC_02108 | SAOUHSC_00365 | Ferritin, putative; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. | Alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Is important for survival under desiccation conditions. Not required for virulence although is necessary for nasal colonization. | 0.703 |
ftnA | hemH | SAOUHSC_02108 | SAOUHSC_01961 | Ferritin, putative; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.595 |
ftnA | hisF | SAOUHSC_02108 | SAOUHSC_03008 | Ferritin, putative; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. | Imidazole glycerol phosphate synthase subunit hisF, putative; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit; In the C-terminal section; belongs to the PRA-PH family. | 0.534 |
ftnA | perR | SAOUHSC_02108 | SAOUHSC_01997 | Ferritin, putative; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. | Ferric uptake regulator-like protein, putative; Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. Regulates expression of genes encoding antioxidant proteins, such as katA, ahpCF, bcp and trxB. Also regulates expression of the iron-storage protein ftn, the ferritin-like protein mrgA, the ferric uptake regulator fur, the manganese transporter operon mntABC, and its own expression. May act as a hydrogen peroxide and organic hydroperoxide sensor. Required for full virulence in a murine skin abscess model of infection. | 0.539 |
ftnA | rpsP | SAOUHSC_02108 | SAOUHSC_01208 | Ferritin, putative; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. | Ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. | 0.407 |
hemH | ftnA | SAOUHSC_01961 | SAOUHSC_02108 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | Ferritin, putative; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. | 0.595 |
hisF | ABD31157.1 | SAOUHSC_03008 | SAOUHSC_02107 | Imidazole glycerol phosphate synthase subunit hisF, putative; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit; In the C-terminal section; belongs to the PRA-PH family. | UDP-N-acetylmuramyl tripeptide synthetase, putative. | 0.451 |
hisF | ftnA | SAOUHSC_03008 | SAOUHSC_02108 | Imidazole glycerol phosphate synthase subunit hisF, putative; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit; In the C-terminal section; belongs to the PRA-PH family. | Ferritin, putative; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. | 0.534 |
perR | ahpC | SAOUHSC_01997 | SAOUHSC_00365 | Ferric uptake regulator-like protein, putative; Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. Regulates expression of genes encoding antioxidant proteins, such as katA, ahpCF, bcp and trxB. Also regulates expression of the iron-storage protein ftn, the ferritin-like protein mrgA, the ferric uptake regulator fur, the manganese transporter operon mntABC, and its own expression. May act as a hydrogen peroxide and organic hydroperoxide sensor. Required for full virulence in a murine skin abscess model of infection. | Alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Is important for survival under desiccation conditions. Not required for virulence although is necessary for nasal colonization. | 0.735 |
perR | ftnA | SAOUHSC_01997 | SAOUHSC_02108 | Ferric uptake regulator-like protein, putative; Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. Regulates expression of genes encoding antioxidant proteins, such as katA, ahpCF, bcp and trxB. Also regulates expression of the iron-storage protein ftn, the ferritin-like protein mrgA, the ferric uptake regulator fur, the manganese transporter operon mntABC, and its own expression. May act as a hydrogen peroxide and organic hydroperoxide sensor. Required for full virulence in a murine skin abscess model of infection. | Ferritin, putative; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. | 0.539 |
rpsP | ftnA | SAOUHSC_01208 | SAOUHSC_02108 | Ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. | Ferritin, putative; Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily. | 0.407 |