Conserved hypothetical protein; May be involved in countering the first line of host defense mechanisms. Impairs the leukocyte response to FPRL1 agonists by binding directly to host FPRL1 (By similarity); Belongs to the CHIPS/FLIPr family.

Truncated beta-hemolysin; Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine; Belongs to the neutral sphingomyelinase family.

Alpha-hemolysin precursor; Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity (By similarity). Belongs to the aerolysin family.

Conserved hypothetical protein; Plays a role in the inhibition of host complement-mediated lysis and serum bactericidal activity by interacting with complement component C5. Affects all three pathways of complement activation and inhibits the cleavage of C5 by preventing its binding to C5 convertases. In turn, prevents C5a-mediated neutrophil migration.

Immunoglobulin G-binding protein Sbi, putative; Plays a role in the inhibition of both the innate and adaptive immune responses. Possesses two N-terminal domains that bind the Fc region of IgG and two domains that form a tripartite complex with complement factors C3b and CFH. By recruiting CFH and C3b, the secreted form acts as a potent complement inhibitor of the alternative pathway-mediated lysis; Belongs to the immunoglobulin-binding protein Sbi family.

Conserved hypothetical protein; Secreted protein that plays a role in the inhibition of host innate immune system. Modulates the interaction between host SELPLG and P-selectin thereby preventing initial rolling of neutrophils toward the site of infection. Interferes with leukocyte trafficking by inhibiting host metalloproteinase-9/MMP9 activity. Associates also with two different platelet surface receptors GP1A and GP6 leading to platelet activation and aggregation. Belongs to the staphylococcal/streptococcal toxin family.

Clumping factor; Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis. Enhances spleen c [...]

Fibrinogen-binding protein.

Conserved hypothetical protein; Secreted protein that plays an essential role in immune innate response inhibition by interacting with and inhibiting host TLR2. In turn, bacteria recognition by immune cells is impaired and cytokine production is inhibited. Mechanistically, by interacting with TLR2, blocks ligand binding and thus inhibits activation. Second, by interacting with an already formed TLR2-lipopeptide complex, prevents TLR heterodimerization and downstream signaling. The interaction with host TLR2 does not involve sialyl Lewis X interactions. Belongs to the staphylococcal/str [...]