STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABD31280.1Integrase; Belongs to the 'phage' integrase family. (345 aa)    
Predicted Functional Partners:
hlb
Truncated beta-hemolysin; Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine; Belongs to the neutral sphingomyelinase family.
  
  
 0.792
ABD31140.1
Integrase, phage family, putative; Belongs to the 'phage' integrase family.
  
     0.614
ABD31279.1
Phi PVL ORF 30-like protein.
       0.542
ABD29897.1
Conserved hypothetical protein.
  
    0.477
whiA
Conserved hypothetical protein; Involved in cell division and chromosome segregation.
  
    0.457
scn
Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses; Belongs to the SCIN family.
      
 0.456
chp
Conserved hypothetical phage protein; Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses (By similarity). Prevents phagocytosis of the bacterium; Belongs to the CHIPS/FLIPr family.
      
 0.455
ABD29374.1
Conserved hypothetical protein; Belongs to the enoyl-CoA hydratase/isomerase family.
   
 
  0.444
ABD31236.1
Prohead protease.
  
   
 0.429
ABD31226.1
Tail length tape measure protein.
  
   
 0.422
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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