| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABD31347.1 | kdpA | SAOUHSC_02313 | SAOUHSC_02312 | Hypothetical protein. | Potassium-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. | 0.969 |
| ABD31347.1 | kdpB | SAOUHSC_02313 | SAOUHSC_02311 | Hypothetical protein. | Potassium-translocating P-type ATPase, B subunit, putative; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. | 0.950 |
| ABD31347.1 | kdpC | SAOUHSC_02313 | SAOUHSC_02310 | Hypothetical protein. | Potassium-transporting ATPase, C subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. | 0.947 |
| ABD31347.1 | kdpD | SAOUHSC_02313 | SAOUHSC_02314 | Hypothetical protein. | Sensor protein KdpD, putative; Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations. Regulates also capsular polysaccharide production. May function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals. In turn, KpdE functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh. | 0.529 |
| ABD31347.1 | kdpE | SAOUHSC_02313 | SAOUHSC_02315 | Hypothetical protein. | DNA-binding response regulator, putative; Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations. Regulates also capsular polysaccharide synthesis. Upon phosphorylation by KpdD, functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh. Represses the transcription of kdpFABC operon. | 0.529 |
| cntC | kdpA | SAOUHSC_02765 | SAOUHSC_02312 | Nickel ABC transporter, permease protein, putative; Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP). Involved in the import of divalent metals ions such as nickel, cobalt and zinc. Probably responsible for the translocation of the substrate across the membrane. Plays a major role in nickel/cobalt import in zinc-depleted conditions. Contributes to virulence. Required for full urease activity in vitro ; Belongs to the binding-protein-dependent transport system permease family. | Potassium-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. | 0.455 |
| kdpA | ABD31347.1 | SAOUHSC_02312 | SAOUHSC_02313 | Potassium-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. | Hypothetical protein. | 0.969 |
| kdpA | cntC | SAOUHSC_02312 | SAOUHSC_02765 | Potassium-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. | Nickel ABC transporter, permease protein, putative; Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP). Involved in the import of divalent metals ions such as nickel, cobalt and zinc. Probably responsible for the translocation of the substrate across the membrane. Plays a major role in nickel/cobalt import in zinc-depleted conditions. Contributes to virulence. Required for full urease activity in vitro ; Belongs to the binding-protein-dependent transport system permease family. | 0.455 |
| kdpA | kdpB | SAOUHSC_02312 | SAOUHSC_02311 | Potassium-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. | Potassium-translocating P-type ATPase, B subunit, putative; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. | 0.999 |
| kdpA | kdpC | SAOUHSC_02312 | SAOUHSC_02310 | Potassium-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. | Potassium-transporting ATPase, C subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. | 0.999 |
| kdpA | kdpD | SAOUHSC_02312 | SAOUHSC_02314 | Potassium-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. | Sensor protein KdpD, putative; Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations. Regulates also capsular polysaccharide production. May function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals. In turn, KpdE functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh. | 0.987 |
| kdpA | kdpE | SAOUHSC_02312 | SAOUHSC_02315 | Potassium-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. | DNA-binding response regulator, putative; Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations. Regulates also capsular polysaccharide synthesis. Upon phosphorylation by KpdD, functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh. Represses the transcription of kdpFABC operon. | 0.901 |
| kdpB | ABD31347.1 | SAOUHSC_02311 | SAOUHSC_02313 | Potassium-translocating P-type ATPase, B subunit, putative; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. | Hypothetical protein. | 0.950 |
| kdpB | kdpA | SAOUHSC_02311 | SAOUHSC_02312 | Potassium-translocating P-type ATPase, B subunit, putative; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. | Potassium-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. | 0.999 |
| kdpB | kdpC | SAOUHSC_02311 | SAOUHSC_02310 | Potassium-translocating P-type ATPase, B subunit, putative; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. | Potassium-transporting ATPase, C subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. | 0.999 |
| kdpB | kdpD | SAOUHSC_02311 | SAOUHSC_02314 | Potassium-translocating P-type ATPase, B subunit, putative; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. | Sensor protein KdpD, putative; Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations. Regulates also capsular polysaccharide production. May function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals. In turn, KpdE functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh. | 0.990 |
| kdpB | kdpE | SAOUHSC_02311 | SAOUHSC_02315 | Potassium-translocating P-type ATPase, B subunit, putative; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. | DNA-binding response regulator, putative; Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations. Regulates also capsular polysaccharide synthesis. Upon phosphorylation by KpdD, functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh. Represses the transcription of kdpFABC operon. | 0.891 |
| kdpC | ABD31347.1 | SAOUHSC_02310 | SAOUHSC_02313 | Potassium-transporting ATPase, C subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. | Hypothetical protein. | 0.947 |
| kdpC | kdpA | SAOUHSC_02310 | SAOUHSC_02312 | Potassium-transporting ATPase, C subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. | Potassium-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. | 0.999 |
| kdpC | kdpB | SAOUHSC_02310 | SAOUHSC_02311 | Potassium-transporting ATPase, C subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. | Potassium-translocating P-type ATPase, B subunit, putative; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. | 0.999 |
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