| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABD31383.1 | ABD31386.1 | SAOUHSC_02352 | SAOUHSC_02355 | UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | Conserved hypothetical protein; Belongs to the UPF0340 family. | 0.601 |
| ABD31383.1 | glyA | SAOUHSC_02352 | SAOUHSC_02354 | UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.729 |
| ABD31383.1 | upp | SAOUHSC_02352 | SAOUHSC_02353 | UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.759 |
| ABD31386.1 | ABD31383.1 | SAOUHSC_02355 | SAOUHSC_02352 | Conserved hypothetical protein; Belongs to the UPF0340 family. | UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | 0.601 |
| ABD31386.1 | glyA | SAOUHSC_02355 | SAOUHSC_02354 | Conserved hypothetical protein; Belongs to the UPF0340 family. | Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.809 |
| ABD31386.1 | lacB | SAOUHSC_02355 | SAOUHSC_02454 | Conserved hypothetical protein; Belongs to the UPF0340 family. | Galactose-6-phosphate isomerase, LacB subunit. | 0.688 |
| ABD31386.1 | upp | SAOUHSC_02355 | SAOUHSC_02353 | Conserved hypothetical protein; Belongs to the UPF0340 family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.766 |
| glyA | ABD31383.1 | SAOUHSC_02354 | SAOUHSC_02352 | Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | 0.729 |
| glyA | ABD31386.1 | SAOUHSC_02354 | SAOUHSC_02355 | Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Conserved hypothetical protein; Belongs to the UPF0340 family. | 0.809 |
| glyA | lacB | SAOUHSC_02354 | SAOUHSC_02454 | Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Galactose-6-phosphate isomerase, LacB subunit. | 0.921 |
| glyA | upp | SAOUHSC_02354 | SAOUHSC_02353 | Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.953 |
| lacB | ABD31386.1 | SAOUHSC_02454 | SAOUHSC_02355 | Galactose-6-phosphate isomerase, LacB subunit. | Conserved hypothetical protein; Belongs to the UPF0340 family. | 0.688 |
| lacB | glyA | SAOUHSC_02454 | SAOUHSC_02354 | Galactose-6-phosphate isomerase, LacB subunit. | Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.921 |
| lacB | upp | SAOUHSC_02454 | SAOUHSC_02353 | Galactose-6-phosphate isomerase, LacB subunit. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.868 |
| pdp | psuG | SAOUHSC_02377 | SAOUHSC_00292 | Pyrimidine nucleoside phosphorylase, putative; Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | Conserved hypothetical protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. | 0.900 |
| pdp | pyrR | SAOUHSC_02377 | SAOUHSC_01164 | Pyrimidine nucleoside phosphorylase, putative; Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | PyrR bifunctional protein; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.923 |
| pdp | udk | SAOUHSC_02377 | SAOUHSC_01715 | Pyrimidine nucleoside phosphorylase, putative; Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | Uridine kinase. | 0.958 |
| pdp | upp | SAOUHSC_02377 | SAOUHSC_02353 | Pyrimidine nucleoside phosphorylase, putative; Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.947 |
| psuG | pdp | SAOUHSC_00292 | SAOUHSC_02377 | Conserved hypothetical protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. | Pyrimidine nucleoside phosphorylase, putative; Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | 0.900 |
| psuG | pyrR | SAOUHSC_00292 | SAOUHSC_01164 | Conserved hypothetical protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. | PyrR bifunctional protein; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.920 |
