STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABD31433.1Conserved hypothetical protein. (2478 aa)    
Predicted Functional Partners:
spa
Protein A; Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins. In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteoge [...]
 
 0.953
ABD31296.1
Conserved hypothetical protein.
  
 0.764
ABD31010.1
Intracellular serine protease, putative; Belongs to the peptidase S8 family.
   
 0.621
ABD29936.1
Conserved hypothetical protein.
    
 
 0.612
ABD30519.1
Conserved hypothetical protein; Belongs to the peptidase S41A family.
   
   0.605
ABD29324.1
Conserved hypothetical protein; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 
 0.591
essC
Conserved hypothetical protein; Component of the type VII secretion system (Ess). Required for the secretion of substrates including EsxA and EsxB. However, unable to support secretion of the substrate protein EsxC. Belongs to the EssC family.
    
   0.591
ABD30354.1
Conserved hypothetical protein; Belongs to the FtsK/SpoIIIE/SftA family.
    
   0.591
ABD30923.1
Conserved hypothetical protein; Belongs to the FtsK/SpoIIIE/SftA family.
    
   0.591
ABD31195.1
Conserved hypothetical protein.
  
    0.583
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.