STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sepAConserved hypothetical protein; Involved in multidrug efflux; Belongs to the multidrug resistance efflux pump SepA family. (157 aa)    
Predicted Functional Partners:
ABD31445.1
Conserved hypothetical protein.
       0.712
ABD31443.1
Conserved hypothetical protein; Belongs to the major facilitator superfamily.
       0.602
mepA
Conserved hypothetical protein; Multidrug resistance efflux protein involved in transporting several clinically relevant monovalent and divalent biocides and the fluoroquinolone antimicrobial agents norfloxacin and ciprofloxacin. Required for transcription of agr and RNAIII and involved in the production of protein A (spa) and toxins alpha, beta and delta.
      
 0.597
norB
Conserved hypothetical protein; Multidrug efflux pump that acts independently of NorA and is one of the factors that confers resistance against diverse quinolones and chemical compounds. Extrudes norfloxacin, ciprofloxacin, cetrimide, tetraphenylphosphonium ion (TPP), sparfloxacin, moxifloxacin and ethidium bromide. Contributes also to the efflux of tetracycline.
      
 0.573
ABD31446.1
Conserved hypothetical protein.
       0.464
ABD31447.1
UDP-N-acetylglucosamine pyrophosphorylase, putative; Belongs to the UDPGP type 1 family.
       0.451
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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