| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABD29457.1 | hrtB | SAOUHSC_00287 | SAOUHSC_02641 | ABC transporter, ATP-binding protein, putative. | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | 0.777 |
| ABD29457.1 | hssS | SAOUHSC_00287 | SAOUHSC_02644 | ABC transporter, ATP-binding protein, putative. | Sensor histidine kinase, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.407 |
| ABD29800.1 | hrtB | SAOUHSC_00667 | SAOUHSC_02641 | ABC transporter ATP-binding protein, putative. | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | 0.554 |
| ABD30095.1 | hrtB | SAOUHSC_00970 | SAOUHSC_02641 | ABC transporter, ATP-binding protein, putative. | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | 0.554 |
| ABD30095.1 | hssS | SAOUHSC_00970 | SAOUHSC_02644 | ABC transporter, ATP-binding protein, putative. | Sensor histidine kinase, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.415 |
| ABD31945.1 | hrtB | SAOUHSC_02954 | SAOUHSC_02641 | ABC transporter, ATP-binding protein, putative. | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | 0.554 |
| ABD32021.1 | hrtB | SAOUHSC_03036 | SAOUHSC_02641 | ABC transporter, ATP-binding protein, putative. | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | 0.554 |
| hrtA | hrtB | SAOUHSC_02640 | SAOUHSC_02641 | Conserved hypothetical protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity). | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | 0.997 |
| hrtA | hssR | SAOUHSC_02640 | SAOUHSC_02643 | Conserved hypothetical protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity). | DNA-binding response regulator, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.916 |
| hrtA | hssS | SAOUHSC_02640 | SAOUHSC_02644 | Conserved hypothetical protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity). | Sensor histidine kinase, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.919 |
| hrtB | ABD29457.1 | SAOUHSC_02641 | SAOUHSC_00287 | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | ABC transporter, ATP-binding protein, putative. | 0.777 |
| hrtB | ABD29800.1 | SAOUHSC_02641 | SAOUHSC_00667 | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | ABC transporter ATP-binding protein, putative. | 0.554 |
| hrtB | ABD30095.1 | SAOUHSC_02641 | SAOUHSC_00970 | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | ABC transporter, ATP-binding protein, putative. | 0.554 |
| hrtB | ABD31945.1 | SAOUHSC_02641 | SAOUHSC_02954 | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | ABC transporter, ATP-binding protein, putative. | 0.554 |
| hrtB | ABD32021.1 | SAOUHSC_02641 | SAOUHSC_03036 | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | ABC transporter, ATP-binding protein, putative. | 0.554 |
| hrtB | hrtA | SAOUHSC_02641 | SAOUHSC_02640 | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | Conserved hypothetical protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity). | 0.997 |
| hrtB | hssR | SAOUHSC_02641 | SAOUHSC_02643 | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | DNA-binding response regulator, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.912 |
| hrtB | hssS | SAOUHSC_02641 | SAOUHSC_02644 | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | Sensor histidine kinase, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.924 |
| hrtB | isdC | SAOUHSC_02641 | SAOUHSC_01082 | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | Conserved hypothetical protein; Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin-free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). | 0.455 |
| hrtB | nadE | SAOUHSC_02641 | SAOUHSC_02132 | Permease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.475 |
