STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABD31673.1Conserved hypothetical protein. (140 aa)    
Predicted Functional Partners:
ABD31586.1
Conserved hypothetical protein.
  
   
 0.656
rsbW
Anti-sigma B factor, putative; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B) (By similarity).
  
    0.590
ABD30882.1
Conserved hypothetical protein.
  
    0.589
ABD31672.1
Transcriptional regulator, putative.
       0.570
ABD29957.1
Conserved hypothetical protein; Belongs to the OsmC/Ohr family.
 
    0.553
ABD31814.1
Conserved hypothetical protein.
  
    0.550
ABD30548.1
Conserved hypothetical protein; Belongs to the UPF0398 family.
  
     0.517
rsbV
STAS domain, putative; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity); Belongs to the anti-sigma-factor antagonist family.
  
    0.503
ABD30899.1
Conserved hypothetical protein.
  
    0.486
ptpA
Conserved hypothetical protein; Secreted tyrosine phosphatase that plays a critical role during infection as a bacterial effector protein that counteracts host defenses. Required for intramacrophage survival.
   
    0.464
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.