| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABD30386.1 | ABD31678.1 | SAOUHSC_01287 | SAOUHSC_02670 | Glutamine synthetase, type I. | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | 0.729 |
| ABD30386.1 | dnaJ | SAOUHSC_01287 | SAOUHSC_01682 | Glutamine synthetase, type I. | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.408 |
| ABD31492.1 | ABD31678.1 | SAOUHSC_02472 | SAOUHSC_02670 | Conserved hypothetical protein. | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | 0.749 |
| ABD31492.1 | dnaJ | SAOUHSC_02472 | SAOUHSC_01682 | Conserved hypothetical protein. | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.652 |
| ABD31492.1 | dnaK | SAOUHSC_02472 | SAOUHSC_01683 | Conserved hypothetical protein. | DNAk protein, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.884 |
| ABD31492.1 | grpE | SAOUHSC_02472 | SAOUHSC_01684 | Conserved hypothetical protein. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.684 |
| ABD31492.1 | hslU | SAOUHSC_02472 | SAOUHSC_01226 | Conserved hypothetical protein. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.448 |
| ABD31678.1 | ABD30386.1 | SAOUHSC_02670 | SAOUHSC_01287 | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | Glutamine synthetase, type I. | 0.729 |
| ABD31678.1 | ABD31492.1 | SAOUHSC_02670 | SAOUHSC_02472 | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | Conserved hypothetical protein. | 0.749 |
| ABD31678.1 | clpB | SAOUHSC_02670 | SAOUHSC_00912 | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.749 |
| ABD31678.1 | clpC | SAOUHSC_02670 | SAOUHSC_00505 | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | Endopeptidase, putative; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. Required for biofilm formation. May act as a chaperone regulating CtsR activity. | 0.749 |
| ABD31678.1 | clpL | SAOUHSC_02670 | SAOUHSC_02862 | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent Clp protease, ATP-binding subunit ClpC, putative; Required for the development of induced thermotolerance and intracellular multiplication within bovine mammary epithelial cells. | 0.749 |
| ABD31678.1 | dnaJ | SAOUHSC_02670 | SAOUHSC_01682 | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.645 |
| ABD31678.1 | dnaK | SAOUHSC_02670 | SAOUHSC_01683 | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | DNAk protein, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.772 |
| ABD31678.1 | grpE | SAOUHSC_02670 | SAOUHSC_01684 | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.589 |
| ABD31678.1 | hslU | SAOUHSC_02670 | SAOUHSC_01226 | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.502 |
| ABD31678.1 | hslV | SAOUHSC_02670 | SAOUHSC_01225 | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | Heat shock protein HslV, putative; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.545 |
| clpB | ABD31678.1 | SAOUHSC_00912 | SAOUHSC_02670 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | 0.749 |
| clpB | dnaJ | SAOUHSC_00912 | SAOUHSC_01682 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.807 |
| clpB | dnaK | SAOUHSC_00912 | SAOUHSC_01683 | ATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | DNAk protein, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.960 |
