STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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sarTStaphylococcal accessory regulator T, putative; Transcriptional regulator acting as an intermediary between major regulators sarA and agr and virulence genes. Represses alpha- hemolysin (hla) gene expression. Down-regulates agr RNAIII expression by repressing sarU, a positive activator of agr expression. Up- regulates sarS, which induces the expression of the cell wall- associated protein A (spa). (106 aa)    
Predicted Functional Partners:
hly
Alpha-hemolysin precursor; Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity (By similarity). Belongs to the aerolysin family.
      
 0.832
sarV
Conserved hypothetical protein; Part of the pathway by which MgrA and SarA control autolysis. Involved in regulation of virulence and autolysis genes such as hla, splA, aur, scp, lrgB, scdA and atl. May also act as an activator for the expression of regulatory genes agr, lytSR and ArlRS.
      
 0.560
sarR
Conserved hypothetical protein; Negative regulator of sarA transcription at late exponential and stationary growth phases. It contributes to the modulation of target genes downstream of the sarA regulatory cascade. Also, positively regulates expression of primary transcripts RNAII and RNAIII generated by agr (virulence accessory gene regulator) locus.
      
 0.548
sarX
Conserved hypothetical protein; Involved in the regulation of virulence genes. Acts as a repressor of the agr locus and consequently targets genes regulated by the agr system such as sspA, hla and hlb. Binds directly to the agr promoter region.
      
 0.541
sasG
Conserved hypothetical protein; Promotes adhesion of bacterial cells to human squamous nasal epithelial cells, a phenomenon which is likely to be important in nasal colonization. Forms short, extremely dense and thin fibrils all over the bacterial surface. Does not bind to either buccal cells or non- differentiated keratinocytes. Promotes cellular aggregation leading to biofilm formation.
     
 0.517
sarZ
Conserved hypothetical protein; Activates transcription of virulence factors alpha- and beta hemolysin genes (hla and hlb). Also, activates RNAIII expression, a central regulator transcribed from the agr locus.
      
 0.499
sarU
Conserved hypothetical protein; Positive regulator of RNAII and RNAIII in a cell density- dependent manner. It can contribute to the expression of virulence genes controlled by agr. May also regulate target genes via an agr- independent pathway.
     
0.467
mgrA
Conserved hypothetical protein; Regulatory protein involved in autolytic activity, multidrug resistance and virulence. Controls autolysis by inactivating LytM, LytN (autolysins) and SarV (autolysis activator) and activating ArlRS, LrgAB and LytSR (autolysis inhibitors). Acts as a dual regulator for resistance to multiple drugs by inactivating NorB and tet38 and activating NorA. Positively controls the expression of virulence accessory gene regulator (agr) to promote alpha-hemolysin (hla) transcription and down-regulates staphylococcal accessory regulator (sarS), leading to repression o [...]
      
 0.414
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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