| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABD30617.1 | clpL | SAOUHSC_01536 | SAOUHSC_02862 | Scaffolding protease; Belongs to the peptidase S14 family. | ATP-dependent Clp protease, ATP-binding subunit ClpC, putative; Required for the development of induced thermotolerance and intracellular multiplication within bovine mammary epithelial cells. | 0.742 |
| ABD30617.1 | clpP | SAOUHSC_01536 | SAOUHSC_00790 | Scaffolding protease; Belongs to the peptidase S14 family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.919 |
| ABD30617.1 | clpX | SAOUHSC_01536 | SAOUHSC_01778 | Scaffolding protease; Belongs to the peptidase S14 family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.971 |
| ABD30617.1 | dnaJ | SAOUHSC_01536 | SAOUHSC_01682 | Scaffolding protease; Belongs to the peptidase S14 family. | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.505 |
| ABD30617.1 | dnaK | SAOUHSC_01536 | SAOUHSC_01683 | Scaffolding protease; Belongs to the peptidase S14 family. | DNAk protein, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.521 |
| ABD30617.1 | grpE | SAOUHSC_01536 | SAOUHSC_01684 | Scaffolding protease; Belongs to the peptidase S14 family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.584 |
| ABD30617.1 | mcsB | SAOUHSC_01536 | SAOUHSC_00504 | Scaffolding protease; Belongs to the peptidase S14 family. | ATP:guanido phosphotransferase, C-terminal catalytic domain protein; Catalyzes the specific phosphorylation of arginine residues in proteins (By similarity). Is required for stress tolerance and virulence in S.aureus. Acts as a modulator of the repressor activity of CtsR upon heavy metal and oxidative stress caused by these metal ions. | 0.467 |
| ABD31678.1 | clpL | SAOUHSC_02670 | SAOUHSC_02862 | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent Clp protease, ATP-binding subunit ClpC, putative; Required for the development of induced thermotolerance and intracellular multiplication within bovine mammary epithelial cells. | 0.749 |
| ABD31678.1 | dnaJ | SAOUHSC_02670 | SAOUHSC_01682 | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.645 |
| ABD31678.1 | dnaK | SAOUHSC_02670 | SAOUHSC_01683 | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | DNAk protein, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.772 |
| ABD31678.1 | grpE | SAOUHSC_02670 | SAOUHSC_01684 | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.589 |
| clpL | ABD30617.1 | SAOUHSC_02862 | SAOUHSC_01536 | ATP-dependent Clp protease, ATP-binding subunit ClpC, putative; Required for the development of induced thermotolerance and intracellular multiplication within bovine mammary epithelial cells. | Scaffolding protease; Belongs to the peptidase S14 family. | 0.742 |
| clpL | ABD31678.1 | SAOUHSC_02862 | SAOUHSC_02670 | ATP-dependent Clp protease, ATP-binding subunit ClpC, putative; Required for the development of induced thermotolerance and intracellular multiplication within bovine mammary epithelial cells. | Conserved hypothetical protein; Belongs to the small heat shock protein (HSP20) family. | 0.749 |
| clpL | clpP | SAOUHSC_02862 | SAOUHSC_00790 | ATP-dependent Clp protease, ATP-binding subunit ClpC, putative; Required for the development of induced thermotolerance and intracellular multiplication within bovine mammary epithelial cells. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.874 |
| clpL | clpX | SAOUHSC_02862 | SAOUHSC_01778 | ATP-dependent Clp protease, ATP-binding subunit ClpC, putative; Required for the development of induced thermotolerance and intracellular multiplication within bovine mammary epithelial cells. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.601 |
| clpL | ctsR | SAOUHSC_02862 | SAOUHSC_00502 | ATP-dependent Clp protease, ATP-binding subunit ClpC, putative; Required for the development of induced thermotolerance and intracellular multiplication within bovine mammary epithelial cells. | Conserved hypothetical protein; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | 0.643 |
| clpL | dnaJ | SAOUHSC_02862 | SAOUHSC_01682 | ATP-dependent Clp protease, ATP-binding subunit ClpC, putative; Required for the development of induced thermotolerance and intracellular multiplication within bovine mammary epithelial cells. | DnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.761 |
| clpL | dnaK | SAOUHSC_02862 | SAOUHSC_01683 | ATP-dependent Clp protease, ATP-binding subunit ClpC, putative; Required for the development of induced thermotolerance and intracellular multiplication within bovine mammary epithelial cells. | DNAk protein, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.917 |
| clpL | grpE | SAOUHSC_02862 | SAOUHSC_01684 | ATP-dependent Clp protease, ATP-binding subunit ClpC, putative; Required for the development of induced thermotolerance and intracellular multiplication within bovine mammary epithelial cells. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.758 |
| clpL | mcsB | SAOUHSC_02862 | SAOUHSC_00504 | ATP-dependent Clp protease, ATP-binding subunit ClpC, putative; Required for the development of induced thermotolerance and intracellular multiplication within bovine mammary epithelial cells. | ATP:guanido phosphotransferase, C-terminal catalytic domain protein; Catalyzes the specific phosphorylation of arginine residues in proteins (By similarity). Is required for stress tolerance and virulence in S.aureus. Acts as a modulator of the repressor activity of CtsR upon heavy metal and oxidative stress caused by these metal ions. | 0.639 |
