| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABD29801.1 | ABD31945.1 | SAOUHSC_00668 | SAOUHSC_02954 | ABC transporter permease, putative. | ABC transporter, ATP-binding protein, putative. | 0.799 |
| ABD29801.1 | ABD31946.1 | SAOUHSC_00668 | SAOUHSC_02955 | ABC transporter permease, putative. | Sensor histidine kinase, putative. | 0.861 |
| ABD29801.1 | ABD31947.1 | SAOUHSC_00668 | SAOUHSC_02956 | ABC transporter permease, putative. | DNA-binding response regulator, putative. | 0.697 |
| ABD29801.1 | graS | SAOUHSC_00668 | SAOUHSC_00666 | ABC transporter permease, putative. | Conserved hypothetical protein; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Functions as a sensor protein kinase which phosphorylates GraR through the auxiliary protein GraX. In turn, GraR up-regulates many genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. Confers resistance to vancomycin, polymyxin B, lysozyme and LL-37. | 0.955 |
| ABD30867.1 | ABD31946.1 | SAOUHSC_01799 | SAOUHSC_02955 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein. | Sensor histidine kinase, putative. | 0.644 |
| ABD30867.1 | ABD31947.1 | SAOUHSC_01799 | SAOUHSC_02956 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein. | DNA-binding response regulator, putative. | 0.741 |
| ABD30867.1 | hssS | SAOUHSC_01799 | SAOUHSC_02644 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein. | Sensor histidine kinase, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). | 0.472 |
| ABD30867.1 | saeS | SAOUHSC_01799 | SAOUHSC_00714 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein. | Sensor histidine kinase SaeS, putative; Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator SaeR. SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (hla, hlb), coa, Dnase, spa and cell wall-associated proteins (emp, eap, fnbA). Acts probably downstr [...] | 0.421 |
| ABD31944.1 | ABD31945.1 | SAOUHSC_02953 | SAOUHSC_02954 | Permease, putative domain protein. | ABC transporter, ATP-binding protein, putative. | 0.969 |
| ABD31944.1 | ABD31946.1 | SAOUHSC_02953 | SAOUHSC_02955 | Permease, putative domain protein. | Sensor histidine kinase, putative. | 0.954 |
| ABD31944.1 | ABD31947.1 | SAOUHSC_02953 | SAOUHSC_02956 | Permease, putative domain protein. | DNA-binding response regulator, putative. | 0.872 |
| ABD31944.1 | graS | SAOUHSC_02953 | SAOUHSC_00666 | Permease, putative domain protein. | Conserved hypothetical protein; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Functions as a sensor protein kinase which phosphorylates GraR through the auxiliary protein GraX. In turn, GraR up-regulates many genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. Confers resistance to vancomycin, polymyxin B, lysozyme and LL-37. | 0.834 |
| ABD31945.1 | ABD29801.1 | SAOUHSC_02954 | SAOUHSC_00668 | ABC transporter, ATP-binding protein, putative. | ABC transporter permease, putative. | 0.799 |
| ABD31945.1 | ABD31944.1 | SAOUHSC_02954 | SAOUHSC_02953 | ABC transporter, ATP-binding protein, putative. | Permease, putative domain protein. | 0.969 |
| ABD31945.1 | ABD31946.1 | SAOUHSC_02954 | SAOUHSC_02955 | ABC transporter, ATP-binding protein, putative. | Sensor histidine kinase, putative. | 0.805 |
| ABD31945.1 | ABD31947.1 | SAOUHSC_02954 | SAOUHSC_02956 | ABC transporter, ATP-binding protein, putative. | DNA-binding response regulator, putative. | 0.713 |
| ABD31945.1 | ABD32022.1 | SAOUHSC_02954 | SAOUHSC_03037 | ABC transporter, ATP-binding protein, putative. | Permease, putative. | 0.820 |
| ABD31946.1 | ABD29801.1 | SAOUHSC_02955 | SAOUHSC_00668 | Sensor histidine kinase, putative. | ABC transporter permease, putative. | 0.861 |
| ABD31946.1 | ABD30867.1 | SAOUHSC_02955 | SAOUHSC_01799 | Sensor histidine kinase, putative. | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein. | 0.644 |
| ABD31946.1 | ABD31944.1 | SAOUHSC_02955 | SAOUHSC_02953 | Sensor histidine kinase, putative. | Permease, putative domain protein. | 0.954 |