Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nixAHigh affinity nickel transporter, putative; Secondary nickel transporter. Required for full urease activity; Belongs to the NiCoT transporter (TC 2.A.52) family. (338 aa)    
Predicted Functional Partners:
nikA
Conserved hypothetical protein; Part of the ABC transporter complex NikABCDE (Opp2) involved in nickel import. Binds nickel and transfers it to the membrane-bound permease. Required for full urease activity and plays a significant role in the virulence of S.aureus during urinary tract infection (UTI). May bind nickel via a nickel-chelator.
      
 0.514
ABD32017.1
Conserved hypothetical protein.
       0.465
ureE
Urease accessory protein UreE, putative; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family.
     
 0.453
ABD32019.1
Conserved hypothetical protein; Belongs to the arylamine N-acetyltransferase family.
       0.425
ureD
Urease accessory protein UreD, putative; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
     
 0.418
ABD31754.1
Conserved hypothetical protein.
  
     0.411
nikB
Oligopeptide transporter putative membrane permease domain; Part of the ABC transporter complex NikABCDE (Opp2) involved in nickel import. Probably responsible for the translocation of the substrate across the membrane. Required for full urease activity and plays a significant role in the virulence of S.aureus during urinary tract infection (UTI).
      
 0.405
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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