STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A0D0DPC4Unplaced genomic scaffold scaffold_1122, whole genome shotgun sequence. (307 aa)    
Predicted Functional Partners:
A0A0D0E6P3
Unplaced genomic scaffold scaffold_365, whole genome shotgun sequence.
   
 0.930
A0A0D0DZ36
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
   
 0.924
A0A0D0DW10
Unplaced genomic scaffold scaffold_324, whole genome shotgun sequence.
   
 0.919
A0A0D0DVD4
Unplaced genomic scaffold scaffold_364, whole genome shotgun sequence.
   
 0.903
A0A0D0D4I7
Unplaced genomic scaffold scaffold_1742, whole genome shotgun sequence.
   
 0.899
A0A0D0DT61
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
   
 0.897
A0A0D0DCV1
Unplaced genomic scaffold scaffold_861, whole genome shotgun sequence.
   
 0.893
A0A0D0CCB4
Unplaced genomic scaffold scaffold_1199, whole genome shotgun sequence.
   
 0.888
A0A0D0DID2
Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
   
 0.887
A0A0D0DS26
Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.
   
 0.887
Your Current Organism:
Paxillus rubicundulus
NCBI taxonomy Id: 930991
Other names: P. rubicundulus Ve08.2h10, Paxillus rubicundulus Ve08.2h10
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.