STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdc6Cell division control protein 6; Involved in regulation of DNA replication. (371 aa)    
Predicted Functional Partners:
C448_09168
Replicative DNA helicase / cell division control protein 21 /MCM; COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family.
  
 0.894
priL
DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
  
 0.740
priS
DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]
  
 
 0.724
C448_06418
COG0417 DNA polymerase elongation subunit (family B).
  
 0.676
C448_02968
COG1933 Archaeal DNA polymerase II, large subunit.
 
   
 0.635
C448_02848
Short-chain alcohol dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases).
       0.620
atpE
V-type ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane.
  
     0.612
C448_02973
COG1933 Archaeal DNA polymerase II, large subunit.
 
   
 0.604
C448_02498
Replication factor A; COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins.
  
 
 0.602
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
  
 0.579
Your Current Organism:
Halococcus morrhuae
NCBI taxonomy Id: 931277
Other names: H. morrhuae DSM 1307, Halococcus morrhuae DSM 1307, Halococcus morrhuae JCM 8876, Halococcus morrhuae NRC 16008
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.