| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Hgd_3 | acs | RO07_00870 | RO07_16390 | 3-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | AMP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.820 |
| Hgd_3 | acsA_1 | RO07_00870 | RO07_13145 | 3-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.820 |
| Hgd_3 | acsA_3 | RO07_00870 | RO07_23865 | 3-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.820 |
| Hgd_3 | aldA_2 | RO07_00870 | RO07_00865 | 3-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. | 0.956 |
| Hgd_3 | bclA_3 | RO07_00870 | RO07_23175 | 3-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.820 |
| Hgd_3 | mmsA_1 | RO07_00870 | RO07_09870 | 3-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methylmalonate-semialdehyde dehydrogenase (acylating); Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.909 |
| Hgd_3 | mmsA_2 | RO07_00870 | RO07_08310 | 3-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methylmalonate-semialdehyde dehydrogenase (acylating); Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.909 |
| Hgd_3 | mmsA_3 | RO07_00870 | RO07_04600 | 3-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methylmalonate-semialdehyde dehydrogenase (acylating); Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.909 |
| acs | Hgd_3 | RO07_16390 | RO07_00870 | AMP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.820 |
| acs | acsA_1 | RO07_16390 | RO07_13145 | AMP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.922 |
| acs | acsA_3 | RO07_16390 | RO07_23865 | AMP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.915 |
| acs | aldA_2 | RO07_16390 | RO07_00865 | AMP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. | 0.927 |
| acs | bclA_3 | RO07_16390 | RO07_23175 | AMP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.921 |
| acs | mmsA_1 | RO07_16390 | RO07_09870 | AMP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methylmalonate-semialdehyde dehydrogenase (acylating); Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.927 |
| acs | mmsA_2 | RO07_16390 | RO07_08310 | AMP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methylmalonate-semialdehyde dehydrogenase (acylating); Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.927 |
| acs | mmsA_3 | RO07_16390 | RO07_04600 | AMP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methylmalonate-semialdehyde dehydrogenase (acylating); Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.927 |
| acsA_1 | Hgd_3 | RO07_13145 | RO07_00870 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 3-hydroxyisobutyrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.820 |
| acsA_1 | acs | RO07_13145 | RO07_16390 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | AMP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.922 |
| acsA_1 | acsA_3 | RO07_13145 | RO07_23865 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.920 |
| acsA_1 | aldA_2 | RO07_13145 | RO07_00865 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. | 0.927 |