| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AJC19390.1 | aes_1 | RO07_00750 | RO07_00760 | Aminocarboxymuconate-semialdehyde decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.409 |
| AJC19390.1 | kynU | RO07_00750 | RO07_01635 | Aminocarboxymuconate-semialdehyde decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.486 |
| AJC19390.1 | nbaC | RO07_00750 | RO07_00745 | Aminocarboxymuconate-semialdehyde decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | 0.990 |
| aes_1 | AJC19390.1 | RO07_00760 | RO07_00750 | Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aminocarboxymuconate-semialdehyde decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.409 |
| aes_1 | kynA | RO07_00760 | RO07_01640 | Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.927 |
| aes_1 | kynB | RO07_00760 | RO07_01630 | Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Arylformamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. | 0.900 |
| aes_1 | kynU | RO07_00760 | RO07_01635 | Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.953 |
| hmgA | hpd | RO07_22040 | RO07_11960 | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. | 4-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.996 |
| hmgA | kynA | RO07_22040 | RO07_01640 | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.528 |
| hmgA | kynU | RO07_22040 | RO07_01635 | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.606 |
| hpd | hmgA | RO07_11960 | RO07_22040 | 4-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. | 0.996 |
| hpd | kynA | RO07_11960 | RO07_01640 | 4-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.585 |
| hpd | kynU | RO07_11960 | RO07_01635 | 4-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.473 |
| katA | kynU | RO07_13055 | RO07_01635 | Catalase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the catalase family. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.904 |
| katA | nbaC | RO07_13055 | RO07_00745 | Catalase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the catalase family. | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. | 0.900 |
| kynA | aes_1 | RO07_01640 | RO07_00760 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.927 |
| kynA | hmgA | RO07_01640 | RO07_22040 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. | 0.528 |
| kynA | hpd | RO07_01640 | RO07_11960 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 4-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.585 |
| kynA | kynB | RO07_01640 | RO07_01630 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | Arylformamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. | 0.997 |
| kynA | kynU | RO07_01640 | RO07_01635 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. | 0.998 |
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