| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| lpxB | rlmB_1 | RO07_19875 | RO07_19885 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.830 |
| lpxB | rnhB | RO07_19875 | RO07_19880 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.952 |
| mnmE | rlmB_1 | RO07_08505 | RO07_19885 | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.826 |
| mnmE | rluD | RO07_08505 | RO07_22950 | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | RNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 0.894 |
| mnmE | rplC | RO07_08505 | RO07_06895 | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. | 0.712 |
| mnmE | rplM | RO07_08505 | RO07_12720 | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.795 |
| mnmE | rplU | RO07_08505 | RO07_05500 | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.812 |
| mnmE | ybeB | RO07_08505 | RO07_02640 | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | Ribosome silencing factor; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.734 |
| rlmB_1 | lpxB | RO07_19885 | RO07_19875 | RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.830 |
| rlmB_1 | mnmE | RO07_19885 | RO07_08505 | RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.826 |
| rlmB_1 | rluD | RO07_19885 | RO07_22950 | RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | RNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 0.821 |
| rlmB_1 | rnb | RO07_19885 | RO07_05350 | RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribonuclease II; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.816 |
| rlmB_1 | rnhB | RO07_19885 | RO07_19880 | RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.903 |
| rlmB_1 | rplC | RO07_19885 | RO07_06895 | RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. | 0.786 |
| rlmB_1 | rplM | RO07_19885 | RO07_12720 | RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.822 |
| rlmB_1 | rplT | RO07_19885 | RO07_23430 | RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | 0.776 |
| rlmB_1 | rplU | RO07_19885 | RO07_05500 | RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.796 |
| rlmB_1 | ybeB | RO07_19885 | RO07_02640 | RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribosome silencing factor; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.803 |
| rluD | mnmE | RO07_22950 | RO07_08505 | RNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.894 |
| rluD | rlmB_1 | RO07_22950 | RO07_19885 | RNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | RNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.821 |