STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A067P338Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (677 aa)    
Predicted Functional Partners:
A0A067PXS7
Autophagy-related protein.
   
 0.999
A0A067PGP7
Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.
    
 0.998
A0A067QA28
UBIQUITIN_CONJUGAT_2 domain-containing protein.
  
 0.987
A0A067QEA3
UBIQUITIN_CONJUGAT_2 domain-containing protein.
  
 0.987
A0A067QCX3
HECT domain-containing protein.
    
 0.982
A0A067PPL6
Autophagy-related protein 3.
    
 0.977
A0A067PZQ0
Uncharacterized protein.
    
 0.977
A0A067QMS7
Autophagy_act_C domain-containing protein.
   
 0.925
A0A067Q901
Uncharacterized protein.
  
 0.919
A0A067QAL1
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.916
Your Current Organism:
Jaapia argillacea
NCBI taxonomy Id: 933084
Other names: J. argillacea MUCL 33604, Jaapia argillacea MUCL 33604
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.