A0A067PY59 protein (Jaapia argillacea) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A0A067PY59

Uncharacterized protein. (203 aa)

Predicted Functional Partners:

A0A067QA28

0.991

A0A067QEA3

0.991

A0A067QAR2

0.985

A0A067PQ98

0.984

A0A067Q445

0.981

A0A067PFI6

0.980

A0A067QD22

0.980

A0A067PCW9

0.979

A0A067Q9C6

0.979

A0A067QDN9

0.979

Your Current Organism:

Jaapia argillacea

NCBI taxonomy Id: 933084
Other names: J. argillacea MUCL 33604, Jaapia argillacea MUCL 33604

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A067PCW9	A0A067PFI6	S10_plectin domain-containing protein.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.999
A0A067PCW9	A0A067PQ98	S10_plectin domain-containing protein.	Uncharacterized protein.	0.984
A0A067PCW9	A0A067PY59	S10_plectin domain-containing protein.	Uncharacterized protein.	0.979
A0A067PCW9	A0A067Q445	S10_plectin domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS19 family.	0.999
A0A067PCW9	A0A067Q9C6	S10_plectin domain-containing protein.	40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family.	0.999
A0A067PCW9	A0A067QAR2	S10_plectin domain-containing protein.	Uncharacterized protein.	0.986
A0A067PCW9	A0A067QD22	S10_plectin domain-containing protein.	Uncharacterized protein.	0.999
A0A067PCW9	A0A067QDN9	S10_plectin domain-containing protein.	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family.	0.999
A0A067PFI6	A0A067PCW9	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	S10_plectin domain-containing protein.	0.999
A0A067PFI6	A0A067PQ98	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	Uncharacterized protein.	0.989
A0A067PFI6	A0A067PY59	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	Uncharacterized protein.	0.980
A0A067PFI6	A0A067Q445	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	Uncharacterized protein; Belongs to the universal ribosomal protein uS19 family.	0.999
A0A067PFI6	A0A067Q9C6	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family.	0.999
A0A067PFI6	A0A067QAR2	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	Uncharacterized protein.	0.995
A0A067PFI6	A0A067QD22	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	Uncharacterized protein.	0.999
A0A067PFI6	A0A067QDN9	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family.	0.999
A0A067PQ98	A0A067PCW9	Uncharacterized protein.	S10_plectin domain-containing protein.	0.984
A0A067PQ98	A0A067PFI6	Uncharacterized protein.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.989
A0A067PQ98	A0A067PY59	Uncharacterized protein.	Uncharacterized protein.	0.984
A0A067PQ98	A0A067Q445	Uncharacterized protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS19 family.	0.989

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.855

expected number of edges:

11

PPI enrichment p-value:

2.85e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009156

Ribonucleoside monophosphate biosynthetic process

7 of 49

1.92

3.85

3.20e-10

GO:0072522

Purine-containing compound biosynthetic process

7 of 58

1.84

3.61

5.30e-10

GO:0009260

Ribonucleotide biosynthetic process

7 of 58

1.84

3.61

5.30e-10

GO:0009168

Purine ribonucleoside monophosphate biosynthetic process

6 of 38

1.96

3.61

3.94e-09

GO:0046112

Nucleobase biosynthetic process

4 of 10

2.37

3.38

2.42e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004044

Amidophosphoribosyltransferase activity

2 of 2

2.76

1.18

0.0073

GO:0016814

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

2 of 10

2.06

0.73

0.0441

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

2 of 9

2.11

0.73

0.0441

GO:0046872

Metal ion binding

6 of 627

0.74

0.42

0.0441

GO:0003824

Catalytic activity

11 of 2064

0.49

0.38

0.0038

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5740

Purine ribonucleoside monophosphate biosynthesis

5 of 11

2.42

4.14

6.73e-09

CL:5735

Nucleotide biosynthesis

6 of 30

2.06

3.77

4.39e-09

CL:5744

Purine nucleobase metabolic process, and Class II PurE

4 of 5

2.67

3.77

7.99e-08

CL:5573

Mixed, incl. Metabolism of nucleotides, and Cellular modified amino acid metabolic process

10 of 149

1.59

3.35

6.95e-13

CL:5581

Nucleoside monophosphate phosphorylation, and Drug ADME

4 of 15

2.19

2.85

1.90e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

8 of 97

1.68

3.33

7.55e-11

map00250

Alanine, aspartate and glutamate metabolism

4 of 25

1.97

2.52

4.31e-06

map00670

One carbon pool by folate

2 of 18

1.81

0.94

0.0147

map01100

Metabolic pathways

10 of 959

0.78

0.77

3.44e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-15869

Metabolism of nucleotides

9 of 65

1.9

4.75

8.61e-14

MAP-8956320

Nucleotide biosynthesis

7 of 38

2.03

4.34

5.98e-11

MAP-73817

Purine ribonucleoside monophosphate biosynthesis

6 of 36

1.99

3.59

5.86e-09

MAP-1430728

Metabolism

10 of 631

0.96

1.11

1.70e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

10 of 1726

0.53

0.38

0.0104

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

4 of 6

2.59

3.56

1.82e-07

KW-0460

Magnesium

4 of 45

1.71

1.8

8.87e-05

KW-0630

Potassium

2 of 6

2.29

1.25

0.0046

KW-0963

Cytoplasm

3 of 105

1.22

0.68

0.0257

KW-0560

Oxidoreductase

2 of 32

1.56

0.67

0.0448

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13522

Glutamine amidotransferase domain

2 of 2

2.76

1.04

0.0130

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017932

Glutamine amidotransferase type 2 domain

2 of 2

2.76

0.77

0.0400

IPR005854

Amidophosphoribosyltransferase

2 of 2

2.76

0.77

0.0400

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