A0A067Q2P2 protein (Jaapia argillacea) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Coexpression

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Score

A0A067Q2P2

FK506-binding protein. (361 aa)

Predicted Functional Partners:

A0A067PTW1

0.939

A0A067P7J3

0.918

ERB1

0.918

A0A067QFR7

0.896

A0A067PTV6

0.895

A0A067QDL7

0.895

A0A067Q3J2

0.885

A0A067QPG8

0.877

A0A067Q974

0.868

A0A067PL50

0.865

Your Current Organism:

Jaapia argillacea

NCBI taxonomy Id: 933084
Other names: J. argillacea MUCL 33604, Jaapia argillacea MUCL 33604

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A067P7J3	A0A067Q2P2	A0A067P7J3	A0A067Q2P2	RING-CH-type domain-containing protein.	FK506-binding protein.	0.918
A0A067PL50	A0A067PTW1	A0A067PL50	A0A067PTW1	Uncharacterized protein.	Brix domain-containing protein.	0.995
A0A067PL50	A0A067Q2P2	A0A067PL50	A0A067Q2P2	Uncharacterized protein.	FK506-binding protein.	0.865
A0A067PL50	A0A067Q3J2	A0A067PL50	A0A067Q3J2	Uncharacterized protein.	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.996
A0A067PL50	A0A067Q974	A0A067PL50	A0A067Q974	Uncharacterized protein.	PUA domain-containing protein.	0.941
A0A067PL50	A0A067QFR7	A0A067PL50	A0A067QFR7	Uncharacterized protein.	Nop domain-containing protein.	0.947
A0A067PL50	A0A067QPG8	A0A067PL50	A0A067QPG8	Uncharacterized protein.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.952
A0A067PL50	ERB1	A0A067PL50	A0A067QMP3	Uncharacterized protein.	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.996
A0A067PTV6	A0A067Q2P2	A0A067PTV6	A0A067Q2P2	Uncharacterized protein.	FK506-binding protein.	0.895
A0A067PTW1	A0A067PL50	A0A067PTW1	A0A067PL50	Brix domain-containing protein.	Uncharacterized protein.	0.995
A0A067PTW1	A0A067Q2P2	A0A067PTW1	A0A067Q2P2	Brix domain-containing protein.	FK506-binding protein.	0.939
A0A067PTW1	A0A067Q3J2	A0A067PTW1	A0A067Q3J2	Brix domain-containing protein.	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.994
A0A067PTW1	A0A067Q974	A0A067PTW1	A0A067Q974	Brix domain-containing protein.	PUA domain-containing protein.	0.926
A0A067PTW1	A0A067QFR7	A0A067PTW1	A0A067QFR7	Brix domain-containing protein.	Nop domain-containing protein.	0.926
A0A067PTW1	A0A067QPG8	A0A067PTW1	A0A067QPG8	Brix domain-containing protein.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.964
A0A067PTW1	ERB1	A0A067PTW1	A0A067QMP3	Brix domain-containing protein.	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.990
A0A067Q2P2	A0A067P7J3	A0A067Q2P2	A0A067P7J3	FK506-binding protein.	RING-CH-type domain-containing protein.	0.918
A0A067Q2P2	A0A067PL50	A0A067Q2P2	A0A067PL50	FK506-binding protein.	Uncharacterized protein.	0.865
A0A067Q2P2	A0A067PTV6	A0A067Q2P2	A0A067PTV6	FK506-binding protein.	Uncharacterized protein.	0.895
A0A067Q2P2	A0A067PTW1	A0A067Q2P2	A0A067PTW1	FK506-binding protein.	Brix domain-containing protein.	0.939

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

16

PPI enrichment p-value:

1.33e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042273

Ribosomal large subunit biogenesis

10 of 77

1.98

5.59

4.57e-16

GO:0000470

Maturation of LSU-rRNA

7 of 41

2.09

4.54

4.47e-11

GO:0000463

Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

6 of 30

2.16

4.16

1.09e-09

GO:0042254

Ribosome biogenesis

11 of 274

1.47

2.94

1.49e-13

GO:0006364

rRNA processing

9 of 204

1.51

2.73

1.85e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043021

Ribonucleoprotein complex binding

3 of 41

1.73

0.75

0.0338

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030687

Preribosome, large subunit precursor

9 of 35

2.27

7.01

7.92e-17

GO:0005730

Nucleolus

11 of 215

1.57

3.56

2.69e-15

GO:0005654

Nucleoplasm

4 of 211

1.14

0.77

0.0085

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4695

Preribosome, large subunit precursor, and Ribosomal large subunit export from nucleus

10 of 28

2.42

8.78

2.32e-20

CL:4698

Preribosome, large subunit precursor, and ATPase binding

9 of 21

2.49

8.61

4.01e-19

CL:4684

Preribosome, large subunit precursor, and DEAD/DEAH box helicase domain

11 of 63

2.1

7.28

2.32e-20

CL:4723

Mixed, incl. Circularly permuted (CP)-type guanine nucleotide-binding (G) domain, and ATPase binding

3 of 6

2.56

2.59

1.45e-05

CL:4700

Maturation of LSU-rRNA, and PUA domain

3 of 10

2.34

2.27

4.62e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

6 of 134

1.51

1.86

9.99e-06

MAP-8868773

rRNA processing in the nucleus and cytosol

6 of 138

1.5

1.84

9.99e-06

MAP-72312

rRNA processing

6 of 141

1.49

1.83

9.99e-06

MAP-8953854

Metabolism of RNA

7 of 553

0.96

0.85

0.00046

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030687

Preribosome, large subunit precursor

3 of 22

2.0

1.6

0.00067

GOCC:0031981

Nuclear lumen

8 of 457

1.11

1.2

1.58e-05

GOCC:0005730

Nucleolus

3 of 98

1.35

0.67

0.0345

GOCC:0005634

Nucleus

9 of 1134

0.76

0.66

0.00023

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0690

Ribosome biogenesis

4 of 18

2.21

2.77

3.05e-06

KW-0698

rRNA processing

3 of 17

2.11

1.85

0.00024

KW-0539

Nucleus

5 of 273

1.13

0.94

0.0014

KW-0489

Methyltransferase

2 of 30

1.69

0.69

0.0458

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030378

Circularly permuted (CP)-type guanine nucleotide-binding (G) domain

2 of 2

2.86

0.89

0.0247

IPR023179

GTP-binding protein, orthogonal bundle domain superfamily

2 of 3

2.69

0.89

0.0247

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