CVT25_001503 protein (Psilocybe cyanescens) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

CVT25_001503

Uncharacterized protein. (529 aa)

Predicted Functional Partners:

CVT25_015429

0.869

CVT25_003539

0.786

CVT25_015625

0.749

CVT25_007349

0.749

CVT25_015699

0.727

CVT25_004235

0.723

CVT25_008701

0.714

CVT25_015036

0.703

CVT25_008582

0.701

CVT25_011820

0.700

Your Current Organism:

Psilocybe cyanescens

NCBI taxonomy Id: 93625
Other names: P. cyanescens, PRM 901481

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT25_001503	CVT25_003539	A0A409WNJ4	A0A409X6Q5	Uncharacterized protein.	Uncharacterized protein; Belongs to the complex I LYR family.	0.786
CVT25_001503	CVT25_004235	A0A409WNJ4	A0A409VS44	Uncharacterized protein.	PlsC domain-containing protein.	0.723
CVT25_001503	CVT25_007349	A0A409WNJ4	A0A409XJF1	Uncharacterized protein.	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	0.749
CVT25_001503	CVT25_008582	A0A409WNJ4	A0A409XNG8	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.701
CVT25_001503	CVT25_008701	A0A409WNJ4	A0A409XNN9	Uncharacterized protein.	Uncharacterized protein.	0.714
CVT25_001503	CVT25_011820	A0A409WNJ4	A0A409WJ46	Uncharacterized protein.	Uncharacterized protein.	0.700
CVT25_001503	CVT25_015036	A0A409WNJ4	A0A409VPM1	Uncharacterized protein.	PlsC domain-containing protein.	0.703
CVT25_001503	CVT25_015429	A0A409WNJ4	A0A409WHE8	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.869
CVT25_001503	CVT25_015625	A0A409WNJ4	A0A409WHY4	Uncharacterized protein.	PlsC domain-containing protein.	0.749
CVT25_001503	CVT25_015699	A0A409WNJ4	A0A409XPM5	Uncharacterized protein.	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	0.727
CVT25_003539	CVT25_001503	A0A409X6Q5	A0A409WNJ4	Uncharacterized protein; Belongs to the complex I LYR family.	Uncharacterized protein.	0.786
CVT25_003539	CVT25_011820	A0A409X6Q5	A0A409WJ46	Uncharacterized protein; Belongs to the complex I LYR family.	Uncharacterized protein.	0.943
CVT25_003539	CVT25_015429	A0A409X6Q5	A0A409WHE8	Uncharacterized protein; Belongs to the complex I LYR family.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.883
CVT25_004235	CVT25_001503	A0A409VS44	A0A409WNJ4	PlsC domain-containing protein.	Uncharacterized protein.	0.723
CVT25_004235	CVT25_007349	A0A409VS44	A0A409XJF1	PlsC domain-containing protein.	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	0.976
CVT25_004235	CVT25_008701	A0A409VS44	A0A409XNN9	PlsC domain-containing protein.	Uncharacterized protein.	0.828
CVT25_004235	CVT25_015036	A0A409VS44	A0A409VPM1	PlsC domain-containing protein.	PlsC domain-containing protein.	0.880
CVT25_004235	CVT25_015625	A0A409VS44	A0A409WHY4	PlsC domain-containing protein.	PlsC domain-containing protein.	0.919
CVT25_004235	CVT25_015699	A0A409VS44	A0A409XPM5	PlsC domain-containing protein.	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	0.946
CVT25_007349	CVT25_001503	A0A409XJF1	A0A409WNJ4	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	Uncharacterized protein.	0.749

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Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.952

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009073

Aromatic amino acid family biosynthetic process

9 of 11

2.34

7.08

2.08e-16

GO:0009423

Chorismate biosynthetic process

6 of 7

2.36

4.68

2.95e-10

GO:0008652

Cellular amino acid biosynthetic process

8 of 49

1.64

3.07

3.86e-10

GO:0009095

Aromatic amino acid family biosynthetic process, prephenate pathway

2 of 2

2.42

1.34

0.0033

GO:0044281

Small molecule metabolic process

10 of 412

0.81

0.82

1.94e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016835

Carbon-oxygen lyase activity

4 of 24

1.65

1.34

0.0012

GO:0016829

Lyase activity

5 of 64

1.32

1.12

0.0012

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27760570

(2016) Rumen metagenome and metatranscriptome analyses of low methane yield sheep reveals a Sharpea-enriched microbiome characterised by lactic acid formation and utilisation.

6 of 23

1.84

2.65

7.71e-07

PMID:37081914

(2023) Comprehensive genomic analysis of hypocholesterolemic probiotic Enterococcus faecium LR13 reveals unique proteins involved in cholesterol-assimilation.

8 of 54

1.59

2.6

2.53e-08

PMID:38078746

(2024) Purine and carbohydrate availability drive Enterococcus faecalis fitness during wound and urinary tract infections.

4 of 12

1.95

1.68

0.00041

PMID:35402559

(2022) Dysbiosis of Gut Microbiota and Metabolite Phenylacetylglutamine in Coronary Artery Disease Patients With Stent Stenosis.

3 of 4

2.3

1.42

0.0022

PMID:15888209

(2005) The TyrA family of aromatic-pathway dehydrogenases in phylogenetic context.

3 of 7

2.06

1.17

0.0059

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1862

Phenylalanine, tyrosine and tryptophan biosynthesis, and ABC transporter substrate binding protein

10 of 16

2.22

7.26

3.12e-18

CL:1865

Phenylalanine, tyrosine and tryptophan biosynthesis

6 of 6

2.42

5.01

8.22e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

efu00400

Phenylalanine, tyrosine and tryptophan biosynthesis

9 of 9

2.42

7.93

5.87e-18

efu01230

Biosynthesis of amino acids

9 of 60

1.6

3.29

3.32e-12

efu01110

Biosynthesis of secondary metabolites

9 of 153

1.19

1.68

6.21e-09

efu01100

Metabolic pathways

9 of 399

0.78

0.74

1.85e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0057

Aromatic amino acid biosynthesis

7 of 7

2.42

5.95

5.37e-13

KW-0456

Lyase

4 of 69

1.19

0.84

0.0060

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