CVT25_004183 protein (Psilocybe cyanescens) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

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[Homology]

Score

CVT25_004183

Uncharacterized protein. (523 aa)

Predicted Functional Partners:

CVT25_012676

0.964

CVT25_012673

0.935

CVT25_011110

0.897

CVT25_005739

0.859

NCS2

0.859

CVT25_006190

0.859

CVT25_006187

0.859

CVT25_006453

0.859

CVT25_008335

0.854

CVT25_004501

0.854

Your Current Organism:

Psilocybe cyanescens

NCBI taxonomy Id: 93625
Other names: P. cyanescens, PRM 901481

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT25_004183	CVT25_004501	A0A409X355	A0A409XRI8	Uncharacterized protein.	CBM21 domain-containing protein.	0.854
CVT25_004183	CVT25_005739	A0A409X355	A0A409VLM7	Uncharacterized protein.	Uncharacterized protein.	0.859
CVT25_004183	CVT25_006187	A0A409X355	A0A409X782	Uncharacterized protein.	Uncharacterized protein.	0.859
CVT25_004183	CVT25_006190	A0A409X355	A0A409X748	Uncharacterized protein.	Uncharacterized protein.	0.859
CVT25_004183	CVT25_006453	A0A409X355	A0A409XE83	Uncharacterized protein.	Uncharacterized protein.	0.859
CVT25_004183	CVT25_008335	A0A409X355	A0A409WV16	Uncharacterized protein.	CBM21 domain-containing protein.	0.854
CVT25_004183	CVT25_011110	A0A409X355	A0A409WGQ6	Uncharacterized protein.	Aamy domain-containing protein.	0.897
CVT25_004183	CVT25_012673	A0A409X355	A0A409VMZ0	Uncharacterized protein.	Uncharacterized protein.	0.935
CVT25_004183	CVT25_012676	A0A409X355	A0A409VN37	Uncharacterized protein.	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.	0.964
CVT25_004183	NCS2	A0A409X355	A0A409VMM2	Uncharacterized protein.	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	0.859
CVT25_004501	CVT25_004183	A0A409XRI8	A0A409X355	CBM21 domain-containing protein.	Uncharacterized protein.	0.854
CVT25_004501	CVT25_005739	A0A409XRI8	A0A409VLM7	CBM21 domain-containing protein.	Uncharacterized protein.	0.842
CVT25_004501	CVT25_006187	A0A409XRI8	A0A409X782	CBM21 domain-containing protein.	Uncharacterized protein.	0.754
CVT25_004501	CVT25_006190	A0A409XRI8	A0A409X748	CBM21 domain-containing protein.	Uncharacterized protein.	0.754
CVT25_004501	CVT25_006453	A0A409XRI8	A0A409XE83	CBM21 domain-containing protein.	Uncharacterized protein.	0.754
CVT25_004501	CVT25_012673	A0A409XRI8	A0A409VMZ0	CBM21 domain-containing protein.	Uncharacterized protein.	0.854
CVT25_004501	NCS2	A0A409XRI8	A0A409VMM2	CBM21 domain-containing protein.	Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.	0.754
CVT25_005739	CVT25_004183	A0A409VLM7	A0A409X355	Uncharacterized protein.	Uncharacterized protein.	0.859
CVT25_005739	CVT25_004501	A0A409VLM7	A0A409XRI8	Uncharacterized protein.	CBM21 domain-containing protein.	0.842
CVT25_005739	CVT25_008335	A0A409VLM7	A0A409WV16	Uncharacterized protein.	CBM21 domain-containing protein.	0.842

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.789

expected number of edges:

10

PPI enrichment p-value:

0.000345

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006084

acetyl-CoA metabolic process

4 of 12

2.07

2.54

6.33e-06

GO:0006086

acetyl-CoA biosynthetic process from pyruvate

3 of 3

2.55

2.45

2.64e-05

GO:0006090

Pyruvate metabolic process

4 of 21

1.83

2.06

3.14e-05

GO:0009150

Purine ribonucleotide metabolic process

7 of 91

1.44

2.0

5.10e-07

GO:0006096

Glycolytic process

3 of 13

1.91

1.66

0.00043

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016624

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

4 of 5

2.45

2.89

3.16e-06

GO:0016417

S-acyltransferase activity

3 of 6

2.25

1.82

0.00034

GO:0004739

Pyruvate dehydrogenase (acetyl-transferring) activity

2 of 3

2.38

1.02

0.0135

GO:0016746

Acyltransferase activity

4 of 133

1.03

0.56

0.0366

GO:0016491

Oxidoreductase activity

6 of 345

0.79

0.5

0.0194

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990204

Oxidoreductase complex

6 of 23

1.97

3.55

6.41e-09

GO:0045252

Oxoglutarate dehydrogenase complex

2 of 2

2.55

1.52

0.0016

GO:0005622

Intracellular anatomical structure

10 of 1324

0.43

0.34

0.0038

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1319

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, and 2-oxoacid dehydrogenase acyltransferase, catalytic domain

9 of 14

2.36

7.46

2.93e-17

CL:1318

Mixed, incl. Oxidoreductase complex, and Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

10 of 22

2.21

7.25

2.37e-18

CL:1321

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor, and e3 binding domain

6 of 7

2.48

5.41

1.54e-11

CL:1271

Mixed, incl. Citrate cycle (TCA cycle), and Aldehyde dehydrogenase domain

11 of 66

1.77

4.82

2.93e-17

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

7 of 25

2.0

4.3

4.93e-11

map01200

Carbon metabolism

8 of 115

1.39

2.19

7.27e-09

map00010

Glycolysis / Gluconeogenesis

4 of 37

1.59

1.69

8.26e-05

map00620

Pyruvate metabolism

4 of 49

1.46

1.48

0.00017

map01120

Microbial metabolism in diverse environments

8 of 255

1.05

1.19

2.17e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

4 of 47

1.48

1.46

0.00022

MAP-9635486

Infection with Mycobacterium tuberculosis

4 of 94

1.18

0.98

0.0015

MAP-5663205

Infectious disease

4 of 105

1.13

0.94

0.0015

MAP-1643685

Disease

4 of 108

1.12

0.93

0.0015

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

7 of 42

1.77

3.24

2.82e-09

GOCC:0045240

Dihydrolipoyl dehydrogenase complex

3 of 3

2.55

2.41

3.19e-05

GOCC:0045252

Oxoglutarate dehydrogenase complex

2 of 2

2.55

1.46

0.0021

GOCC:0005622

Intracellular

11 of 1295

0.48

0.41

0.00031

GOCC:0005737

Cytoplasm

9 of 978

0.52

0.39

0.0054

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0450

Lipoyl

4 of 4

2.55

3.33

4.85e-07

KW-0324

Glycolysis

2 of 10

1.85

0.78

0.0323

KW-0012

Acyltransferase

3 of 43

1.4

0.74

0.0243

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

4 of 4

2.55

3.11

1.32e-06

PF00364

Biotin-requiring enzyme

4 of 6

2.38

2.95

1.98e-06

PF02817

e3 binding domain

3 of 3

2.55

2.26

6.19e-05

PF00676

Dehydrogenase E1 component

2 of 2

2.55

1.21

0.0061

PF02780

Transketolase, C-terminal domain

2 of 3

2.38

1.13

0.0081

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003016

2-oxo acid dehydrogenase, lipoyl-binding site

4 of 4

2.55

2.92

3.21e-06

IPR001078

2-oxoacid dehydrogenase acyltransferase, catalytic domain

4 of 4

2.55

2.92

3.21e-06

IPR011053

Single hybrid motif

4 of 6

2.38

2.85

3.21e-06

IPR000089

Biotin/lipoyl attachment

4 of 6

2.38

2.85

3.21e-06

IPR023213

Chloramphenicol acetyltransferase-like domain superfamily

4 of 8

2.25

2.72

4.51e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

3 of 4

2.43

2.22

6.66e-05

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