CVT25_013697 protein (Psilocybe cyanescens) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

CVT25_013697

Uncharacterized protein. (753 aa)

Predicted Functional Partners:

CVT25_004484

0.716

CVT25_004678

0.687

CVT25_012817

0.619

CVT25_014663

0.617

CVT25_005451

0.609

CVT25_011136

0.609

CVT25_006395

0.609

CVT25_013724

0.596

CVT25_011753

0.593

CVT25_009948

0.593

Your Current Organism:

Psilocybe cyanescens

NCBI taxonomy Id: 93625
Other names: P. cyanescens, PRM 901481

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT25_004484	CVT25_005451	A0A409W375	A0A409VQM0	ABC transmembrane type-1 domain-containing protein.	Uncharacterized protein.	0.609
CVT25_004484	CVT25_006395	A0A409W375	A0A409X3S3	ABC transmembrane type-1 domain-containing protein.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.609
CVT25_004484	CVT25_009948	A0A409W375	A0A409XCP0	ABC transmembrane type-1 domain-containing protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.593
CVT25_004484	CVT25_011136	A0A409W375	A0A409WGU3	ABC transmembrane type-1 domain-containing protein.	AAA domain-containing protein.	0.609
CVT25_004484	CVT25_011753	A0A409W375	A0A409WIE1	ABC transmembrane type-1 domain-containing protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.593
CVT25_004484	CVT25_012817	A0A409W375	A0A409XF68	ABC transmembrane type-1 domain-containing protein.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.619
CVT25_004484	CVT25_013697	A0A409W375	A0A409XLE6	ABC transmembrane type-1 domain-containing protein.	Uncharacterized protein.	0.716
CVT25_004484	CVT25_013724	A0A409W375	A0A409XL54	ABC transmembrane type-1 domain-containing protein.	ENTH domain-containing protein.	0.596
CVT25_004484	CVT25_014663	A0A409W375	A0A409WU74	ABC transmembrane type-1 domain-containing protein.	RING-type domain-containing protein.	0.617
CVT25_004678	CVT25_005451	A0A409XE47	A0A409VQM0	ABC transmembrane type-1 domain-containing protein.	Uncharacterized protein.	0.609
CVT25_004678	CVT25_006395	A0A409XE47	A0A409X3S3	ABC transmembrane type-1 domain-containing protein.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.609
CVT25_004678	CVT25_009948	A0A409XE47	A0A409XCP0	ABC transmembrane type-1 domain-containing protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.593
CVT25_004678	CVT25_011136	A0A409XE47	A0A409WGU3	ABC transmembrane type-1 domain-containing protein.	AAA domain-containing protein.	0.609
CVT25_004678	CVT25_011753	A0A409XE47	A0A409WIE1	ABC transmembrane type-1 domain-containing protein.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.593
CVT25_004678	CVT25_012817	A0A409XE47	A0A409XF68	ABC transmembrane type-1 domain-containing protein.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.619
CVT25_004678	CVT25_013697	A0A409XE47	A0A409XLE6	ABC transmembrane type-1 domain-containing protein.	Uncharacterized protein.	0.687
CVT25_004678	CVT25_013724	A0A409XE47	A0A409XL54	ABC transmembrane type-1 domain-containing protein.	ENTH domain-containing protein.	0.596
CVT25_004678	CVT25_014663	A0A409XE47	A0A409WU74	ABC transmembrane type-1 domain-containing protein.	RING-type domain-containing protein.	0.617
CVT25_005451	CVT25_004484	A0A409VQM0	A0A409W375	Uncharacterized protein.	ABC transmembrane type-1 domain-containing protein.	0.609
CVT25_005451	CVT25_004678	A0A409VQM0	A0A409XE47	Uncharacterized protein.	ABC transmembrane type-1 domain-containing protein.	0.609

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Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.8

expected number of edges:

4

PPI enrichment p-value:

0.116

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046578

Regulation of Ras protein signal transduction

2 of 20

2.23

1.0

0.0366

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030414

Peptidase inhibitor activity

3 of 7

2.86

3.35

1.77e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15107

Mixed, incl. Endoplasmic reticulum tubular network organization, and Glutathione S-transferase Omega/GSH

3 of 24

2.33

2.24

0.00047

CL:15108

Mixed, incl. Glutathione S-transferase Omega/GSH, and Degradation of aromatic compounds

2 of 12

2.45

1.3

0.0140

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04712

Circadian rhythm - plant

2 of 12

2.45

1.69

0.0038

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5674135

MAP2K and MAPK activation

2 of 11

2.49

1.2

0.0199

MAP-5675221

Negative regulation of MAPK pathway

2 of 24

2.15

0.96

0.0414

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01161

Phosphatidylethanolamine-binding protein

2 of 4

2.93

1.72

0.0040

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036610

PEBP-like superfamily

2 of 4

2.93

1.39

0.0115

IPR035810

Phosphatidylethanolamine-binding protein, eukaryotic

2 of 4

2.93

1.39

0.0115

IPR008914

Phosphatidylethanolamine-binding protein

2 of 4

2.93

1.39

0.0115

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