F8PKB9_SERL3 protein (Serpula lacrymans) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

Experiments

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[Homology]

Score

F8PKB9_SERL3

Aldo_ket_red domain-containing protein. (338 aa)

Predicted Functional Partners:

F8QCK3_SERL3

0.743

F8Q5T1_SERL3

0.724

F8Q2Z9_SERL3

0.721

F8Q2G7_SERL3

0.706

F8PIN5_SERL3

0.681

F8Q9E2_SERL3

0.681

F8Q9G3_SERL3

0.674

F8PJ83_SERL3

0.666

F8QD21_SERL3

0.588

F8PSW7_SERL3

0.578

Your Current Organism:

Serpula lacrymans

NCBI taxonomy Id: 936435
Other names: S. lacrymans var. lacrymans S7.3, Serpula lacrymans var. lacrymans S7.3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F8PIN5_SERL3	F8PKB9_SERL3	F8PIN5	F8PKB9	Uncharacterized protein.	Aldo_ket_red domain-containing protein.	0.681
F8PJ83_SERL3	F8PKB9_SERL3	F8PJ83	F8PKB9	Uncharacterized protein; Belongs to the WD repeat SEC13 family.	Aldo_ket_red domain-containing protein.	0.666
F8PJ83_SERL3	F8Q2G7_SERL3	F8PJ83	F8Q2G7	Uncharacterized protein; Belongs to the WD repeat SEC13 family.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.999
F8PJ83_SERL3	F8Q2Z9_SERL3	F8PJ83	F8Q2Z9	Uncharacterized protein; Belongs to the WD repeat SEC13 family.	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	0.999
F8PJ83_SERL3	F8Q5T1_SERL3	F8PJ83	F8Q5T1	Uncharacterized protein; Belongs to the WD repeat SEC13 family.	Uncharacterized protein.	0.999
F8PJ83_SERL3	F8Q9G3_SERL3	F8PJ83	F8Q9G3	Uncharacterized protein; Belongs to the WD repeat SEC13 family.	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).	0.999
F8PJ83_SERL3	F8QD21_SERL3	F8PJ83	F8QD21	Uncharacterized protein; Belongs to the WD repeat SEC13 family.	Uncharacterized protein.	0.943
F8PKB9_SERL3	F8PIN5_SERL3	F8PKB9	F8PIN5	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.681
F8PKB9_SERL3	F8PJ83_SERL3	F8PKB9	F8PJ83	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the WD repeat SEC13 family.	0.666
F8PKB9_SERL3	F8PSW7_SERL3	F8PKB9	F8PSW7	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the cytochrome b5 family.	0.578
F8PKB9_SERL3	F8Q2G7_SERL3	F8PKB9	F8Q2G7	Aldo_ket_red domain-containing protein.	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	0.706
F8PKB9_SERL3	F8Q2Z9_SERL3	F8PKB9	F8Q2Z9	Aldo_ket_red domain-containing protein.	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	0.721
F8PKB9_SERL3	F8Q5T1_SERL3	F8PKB9	F8Q5T1	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.724
F8PKB9_SERL3	F8Q9E2_SERL3	F8PKB9	F8Q9E2	Aldo_ket_red domain-containing protein.	Ribosomal protein L37; Binds to the 23S rRNA.	0.681
F8PKB9_SERL3	F8Q9G3_SERL3	F8PKB9	F8Q9G3	Aldo_ket_red domain-containing protein.	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).	0.674
F8PKB9_SERL3	F8QCK3_SERL3	F8PKB9	F8QCK3	Aldo_ket_red domain-containing protein.	Ion_trans domain-containing protein.	0.743
F8PKB9_SERL3	F8QD21_SERL3	F8PKB9	F8QD21	Aldo_ket_red domain-containing protein.	Uncharacterized protein.	0.588
F8PSW7_SERL3	F8PKB9_SERL3	F8PSW7	F8PKB9	Uncharacterized protein; Belongs to the cytochrome b5 family.	Aldo_ket_red domain-containing protein.	0.578
F8Q2G7_SERL3	F8PJ83_SERL3	F8Q2G7	F8PJ83	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	Uncharacterized protein; Belongs to the WD repeat SEC13 family.	0.999
F8Q2G7_SERL3	F8PKB9_SERL3	F8Q2G7	F8PKB9	WD_REPEATS_REGION domain-containing protein; Belongs to the WD repeat SEC13 family.	Aldo_ket_red domain-containing protein.	0.706

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

22

PPI enrichment p-value:

9.22e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 298

1.49

3.05

1.60e-13

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

11 of 167

1.75

4.58

1.39e-16

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005761

Mitochondrial ribosome

10 of 70

2.08

6.48

1.13e-17

GO:0005762

Mitochondrial large ribosomal subunit

8 of 41

2.22

6.13

8.87e-15

GO:0005840

Ribosome

11 of 183

1.71

4.42

6.79e-17

GO:0044391

Ribosomal subunit

10 of 154

1.74

4.31

4.98e-15

GO:0098798

Mitochondrial protein-containing complex

10 of 177

1.68

3.98

1.09e-14

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4871

Organellar large ribosomal subunit, and Ribosomal protein L23

10 of 18

2.67

10.54

1.79e-22

CL:4863

Organellar ribosome

11 of 53

2.24

8.49

5.45e-22

CL:4893

Organellar large ribosomal subunit

5 of 6

2.85

5.39

7.63e-11

CL:4872

Mixed, incl. Ribosomal protein L23, and Organellar large ribosomal subunit

5 of 10

2.63

4.87

4.40e-10

CL:4874

Mixed, incl. Ribosomal protein L23, and Translation protein SH3-like domain superfamily

3 of 5

2.71

2.67

1.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

11 of 187

1.7

4.39

4.60e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72766

Translation

9 of 253

1.48

2.58

4.66e-10

MAP-392499

Metabolism of proteins

9 of 907

0.92

0.93

1.76e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005762

Mitochondrial large ribosomal subunit

9 of 38

2.3

7.35

1.68e-17

GOCC:0005761

Mitochondrial ribosome

10 of 64

2.12

6.74

5.70e-18

GOCC:0044391

Ribosomal subunit

10 of 141

1.78

4.55

1.97e-15

GOCC:0098798

Mitochondrial protein complex

10 of 168

1.7

4.12

5.94e-15

GOCC:0005739

Mitochondrion

11 of 684

1.13

1.66

3.63e-11

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

7 of 92

1.81

3.45

9.56e-10

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