F8PLH2_SERL3 protein (Serpula lacrymans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

F8PLH2_SERL3

Uncharacterized protein. (147 aa)

Predicted Functional Partners:

F8PQY6_SERL3

0.927

F8PJ75_SERL3

0.692

F8QJB5_SERL3

0.692

F8Q6R0_SERL3

0.628

F8Q7G2_SERL3

0.608

F8PPW6_SERL3

0.603

F8PKV9_SERL3

0.580

F8PWZ1_SERL3

0.550

F8Q2N7_SERL3

0.550

F8PIG8_SERL3

0.548

Your Current Organism:

Serpula lacrymans

NCBI taxonomy Id: 936435
Other names: S. lacrymans var. lacrymans S7.3, Serpula lacrymans var. lacrymans S7.3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F8PIG8_SERL3	F8PLH2_SERL3	F8PIG8	F8PLH2	Uncharacterized protein.	Uncharacterized protein.	0.548
F8PJ75_SERL3	F8PKV9_SERL3	F8PJ75	F8PKV9	ANK_REP_REGION domain-containing protein.	GRIP domain-containing protein.	0.824
F8PJ75_SERL3	F8PLH2_SERL3	F8PJ75	F8PLH2	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.692
F8PJ75_SERL3	F8PPW6_SERL3	F8PJ75	F8PPW6	ANK_REP_REGION domain-containing protein.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.941
F8PJ75_SERL3	F8PQY6_SERL3	F8PJ75	F8PQY6	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.999
F8PJ75_SERL3	F8PWZ1_SERL3	F8PJ75	F8PWZ1	ANK_REP_REGION domain-containing protein.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	0.838
F8PJ75_SERL3	F8Q2N7_SERL3	F8PJ75	F8Q2N7	ANK_REP_REGION domain-containing protein.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.838
F8PJ75_SERL3	F8Q6R0_SERL3	F8PJ75	F8Q6R0	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.658
F8PJ75_SERL3	F8Q7G2_SERL3	F8PJ75	F8Q7G2	ANK_REP_REGION domain-containing protein.	Uncharacterized protein; Belongs to the SKP1 family.	0.824
F8PJ75_SERL3	F8QJB5_SERL3	F8PJ75	F8QJB5	ANK_REP_REGION domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.806
F8PKV9_SERL3	F8PJ75_SERL3	F8PKV9	F8PJ75	GRIP domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.824
F8PKV9_SERL3	F8PLH2_SERL3	F8PKV9	F8PLH2	GRIP domain-containing protein.	Uncharacterized protein.	0.580
F8PKV9_SERL3	F8PQY6_SERL3	F8PKV9	F8PQY6	GRIP domain-containing protein.	Uncharacterized protein.	0.737
F8PKV9_SERL3	F8PWZ1_SERL3	F8PKV9	F8PWZ1	GRIP domain-containing protein.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.	0.580
F8PKV9_SERL3	F8Q2N7_SERL3	F8PKV9	F8Q2N7	GRIP domain-containing protein.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.580
F8PKV9_SERL3	F8QJB5_SERL3	F8PKV9	F8QJB5	GRIP domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.824
F8PLH2_SERL3	F8PIG8_SERL3	F8PLH2	F8PIG8	Uncharacterized protein.	Uncharacterized protein.	0.548
F8PLH2_SERL3	F8PJ75_SERL3	F8PLH2	F8PJ75	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.692
F8PLH2_SERL3	F8PKV9_SERL3	F8PLH2	F8PKV9	Uncharacterized protein.	GRIP domain-containing protein.	0.580
F8PLH2_SERL3	F8PPW6_SERL3	F8PLH2	F8PPW6	Uncharacterized protein.	14_3_3 domain-containing protein; Belongs to the 14-3-3 family.	0.603

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.915

expected number of edges:

10

PPI enrichment p-value:

2.83e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051382

Kinetochore assembly

3 of 12

2.72

1.93

0.00029

GO:0007059

Chromosome segregation

5 of 220

1.68

1.59

0.00029

GO:0000712

Resolution of meiotic recombination intermediates

2 of 17

2.4

0.87

0.0257

GO:0036297

Interstrand cross-link repair

2 of 25

2.23

0.81

0.0327

GO:0031297

Replication fork processing

2 of 29

2.16

0.78

0.0359

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0080122

AMP transmembrane transporter activity

2 of 4

3.02

1.16

0.0082

GO:0015228

Coenzyme A transmembrane transporter activity

2 of 4

3.02

1.16

0.0082

GO:0043262

Adenosine-diphosphatase activity

2 of 7

2.78

1.15

0.0082

GO:0015217

ADP transmembrane transporter activity

2 of 9

2.67

1.15

0.0082

GO:0005347

ATP transmembrane transporter activity

2 of 16

2.42

1.01

0.0140

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000775

Chromosome, centromeric region

5 of 150

1.85

2.32

7.01e-06

GO:0071821

FANCM-MHF complex

2 of 5

2.93

1.58

0.0014

GO:0043240

Fanconi anaemia nuclear complex

2 of 9

2.67

1.4

0.0028

GO:0000776

Kinetochore

3 of 101

1.8

1.24

0.0030

GO:0005694

Chromosome

6 of 900

1.15

1.03

0.00057

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4083

Centromere complex assembly, and AMP transport

7 of 16

2.97

8.07

5.63e-16

CL:4087

Centromere complex assembly, and Inner kinetochore

6 of 11

3.06

7.34

2.20e-14

CL:4090

Centromere complex assembly, and Inner kinetochore

3 of 6

3.02

3.0

3.36e-06

CL:2471

Fanconi anaemia nuclear complex, and CENP-S protein

2 of 12

2.55

1.13

0.0085

CL:2198

DNA replication, and Fanconi anemia pathway

3 of 165

1.58

0.8

0.0229

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

sdu03460

Fanconi anemia pathway

2 of 46

1.96

0.76

0.0376

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-774815

Nucleosome assembly

5 of 62

2.23

3.39

1.30e-07

MAP-606279

Deposition of new CENPA-containing nucleosomes at the centromere

5 of 62

2.23

3.39

1.30e-07

MAP-73886

Chromosome Maintenance

5 of 129

1.91

2.64

1.47e-06

MAP-499943

Interconversion of nucleotide di- and triphosphates

3 of 43

2.17

1.72

0.00049

MAP-141444

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

3 of 108

1.77

1.11

0.0057

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071821

FANCM-MHF complex

2 of 5

2.93

1.44

0.0025

GOCC:0000779

Condensed chromosome, centromeric region

3 of 48

2.12

1.36

0.0025

GOCC:0000776

Kinetochore

3 of 54

2.07

1.35

0.0025

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