STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F8Q3P6_SERL3Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2990 aa)    
Predicted Functional Partners:
F8PQB6_SERL3
Uncharacterized protein; Belongs to the PI3/PI4-kinase family.
   
0.996
F8PN25_SERL3
3'-5' exonuclease domain-containing protein.
   
 0.991
F8PN26_SERL3
3'-5' exonuclease domain-containing protein.
   
 0.991
F8PTH6_SERL3
3'-5' exonuclease domain-containing protein.
   
 0.991
F8QES1_SERL3
Helicase C-terminal domain-containing protein.
   
 0.991
F8PTL4_SERL3
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
   
 0.987
F8Q0R7_SERL3
Uncharacterized protein.
   
 0.981
F8Q2T2_SERL3
Uncharacterized protein.
    
 0.981
F8QEL3_SERL3
Uncharacterized protein.
    
 0.980
F8QAG9_SERL3
Uncharacterized protein.
     
 0.971
Your Current Organism:
Serpula lacrymans
NCBI taxonomy Id: 936435
Other names: S. lacrymans var. lacrymans S7.3, Serpula lacrymans var. lacrymans S7.3
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.