STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAC1Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs; Belongs to the WD repeat LIS1/nudF family. (437 aa)    
Predicted Functional Partners:
F8PMC1_SERL3
Uncharacterized protein.
    
 0.977
F8QC70_SERL3
DHC_N1 domain-containing protein.
    
 0.977
F8PHT9_SERL3
Uncharacterized protein.
    
 
 0.955
F8PWQ1_SERL3
Uncharacterized protein.
    
 0.949
F8Q8R0_SERL3
CS domain-containing protein.
   
 0.936
F8QHL1_SERL3
WD_REPEATS_REGION domain-containing protein.
   
 0.936
F8PU17_SERL3
Uncharacterized protein.
    
 0.925
F8PPY8_SERL3
Uncharacterized protein.
    
 0.904
F8Q8W4_SERL3
Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
    
 0.891
F8PXS9_SERL3
CS domain-containing protein.
   
 0.883
Your Current Organism:
Serpula lacrymans
NCBI taxonomy Id: 936435
Other names: S. lacrymans var. lacrymans S7.3, Serpula lacrymans var. lacrymans S7.3
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.