STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F8Q8C9_SERL3Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (432 aa)    
Predicted Functional Partners:
F8QH83_SERL3
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
  
 
 0.993
F8QHY9_SERL3
MGS domain-containing protein.
  
 0.986
F8PMX9_SERL3
Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.985
F8PPY5_SERL3
Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
   
 0.973
F8Q2N8_SERL3
Uncharacterized protein.
  
 
 0.965
F8PP80_SERL3
Histidine biosynthesis trifunctional protein.
  
  
 0.963
F8Q935_SERL3
Uncharacterized protein.
  
 
 0.963
F8PRJ3_SERL3
Lyase_1 domain-containing protein.
  
 0.952
F8PX76_SERL3
Aspartate aminotransferase.
  
 0.952
F8Q755_SERL3
Aspartate aminotransferase.
  
 0.951
Your Current Organism:
Serpula lacrymans
NCBI taxonomy Id: 936435
Other names: S. lacrymans var. lacrymans S7.3, Serpula lacrymans var. lacrymans S7.3
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