ENSEEUP00000000492 protein (Erinaceus europaeus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSEEUP00000000492

annotation not available (46 aa)

Predicted Functional Partners:

ENSEEUP00000013640

0.991

SKP2

0.989

FBXL5

0.985

KDM2B

0.984

FBXL19

0.982

ENSEEUP00000003494

0.975

KDM2A

0.975

FBXW8

0.969

CDK2

0.969

BTRC

0.966

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTRC	ENSEEUP00000000492	ENSEEUP00000013855	ENSEEUP00000000492	F-box/WD repeat-containing protein 1A isoform X1.	annotation not available	0.966
BTRC	ENSEEUP00000003494	ENSEEUP00000013855	ENSEEUP00000003494	F-box/WD repeat-containing protein 1A isoform X1.	annotation not available	0.974
BTRC	ENSEEUP00000013640	ENSEEUP00000013855	ENSEEUP00000013640	F-box/WD repeat-containing protein 1A isoform X1.	annotation not available	0.998
BTRC	FBXW8	ENSEEUP00000013855	ENSEEUP00000010677	F-box/WD repeat-containing protein 1A isoform X1.	F-box/WD repeat-containing protein 8 isoform X2.	0.614
BTRC	SKP2	ENSEEUP00000013855	ENSEEUP00000001344	F-box/WD repeat-containing protein 1A isoform X1.	S-phase kinase-associated protein 2 isoform X2.	0.935
CDK2	ENSEEUP00000000492	ENSEEUP00000012832	ENSEEUP00000000492	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	annotation not available	0.969
CDK2	ENSEEUP00000013640	ENSEEUP00000012832	ENSEEUP00000013640	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	annotation not available	0.987
CDK2	SKP2	ENSEEUP00000012832	ENSEEUP00000001344	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	S-phase kinase-associated protein 2 isoform X2.	0.997
ENSEEUP00000000492	BTRC	ENSEEUP00000000492	ENSEEUP00000013855	annotation not available	F-box/WD repeat-containing protein 1A isoform X1.	0.966
ENSEEUP00000000492	CDK2	ENSEEUP00000000492	ENSEEUP00000012832	annotation not available	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.969
ENSEEUP00000000492	ENSEEUP00000003494	ENSEEUP00000000492	ENSEEUP00000003494	annotation not available	annotation not available	0.975
ENSEEUP00000000492	ENSEEUP00000013640	ENSEEUP00000000492	ENSEEUP00000013640	annotation not available	annotation not available	0.991
ENSEEUP00000000492	FBXL19	ENSEEUP00000000492	ENSEEUP00000001137	annotation not available	F-box/LRR-repeat protein 19 isoform X1.	0.982
ENSEEUP00000000492	FBXL5	ENSEEUP00000000492	ENSEEUP00000011574	annotation not available	F-box/LRR-repeat protein 5.	0.985
ENSEEUP00000000492	FBXW8	ENSEEUP00000000492	ENSEEUP00000010677	annotation not available	F-box/WD repeat-containing protein 8 isoform X2.	0.969
ENSEEUP00000000492	KDM2A	ENSEEUP00000000492	ENSEEUP00000009301	annotation not available	Lysine-specific demethylase 2A isoform X1.	0.975
ENSEEUP00000000492	KDM2B	ENSEEUP00000000492	ENSEEUP00000005597	annotation not available	Lysine-specific demethylase 2B isoform X2.	0.984
ENSEEUP00000000492	SKP2	ENSEEUP00000000492	ENSEEUP00000001344	annotation not available	S-phase kinase-associated protein 2 isoform X2.	0.989
ENSEEUP00000003494	BTRC	ENSEEUP00000003494	ENSEEUP00000013855	annotation not available	F-box/WD repeat-containing protein 1A isoform X1.	0.974
ENSEEUP00000003494	ENSEEUP00000000492	ENSEEUP00000003494	ENSEEUP00000000492	annotation not available	annotation not available	0.975

page 1 of 4

Network Stats

number of nodes:

10

number of edges:

19

average node degree:

3.8

avg. local clustering coefficient:

0.894

expected number of edges:

11

PPI enrichment p-value:

0.0162

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0002031

G protein-coupled receptor internalization

3 of 6

2.82

2.11

0.00014

GO:0050909

Sensory perception of taste

3 of 27

2.17

1.55

0.0011

GO:0007200

Phospholipase C-activating G protein-coupled receptor signaling pathway

3 of 36

2.04

1.39

0.0020

GO:0007606

Sensory perception of chemical stimulus

6 of 410

1.29

1.25

0.00024

GO:0007191

Adenylate cyclase-activating dopamine receptor signaling pathway

2 of 5

2.73

1.22

0.0062

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001664

G protein-coupled receptor binding

6 of 166

1.68

2.24

2.92e-06

GO:0031690

Adrenergic receptor binding

2 of 9

2.47

0.88

0.0251

GO:0031683

G-protein beta/gamma-subunit complex binding

2 of 12

2.34

0.87

0.0254

GO:0071855

Neuropeptide receptor binding

2 of 16

2.22

0.79

0.0355

GO:0003924

GTPase activity

4 of 214

1.39

0.78

0.0199

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 26

2.41

3.91

2.04e-08

GO:0042995

Cell projection

8 of 1389

0.88

0.81

0.00016

GO:0120025

Plasma membrane bounded cell projection

7 of 1332

0.84

0.67

0.0017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:24323

Mixed, incl. Activation of GABAB receptors, and Amine ligand-binding receptors

5 of 53

2.1

2.86

1.18e-06

CL:24314

GPCR ligand binding, and G-protein mediated events

6 of 149

1.73

2.43

1.18e-06

CL:24328

Activation of GABAB receptors, and Dopamine receptor family

3 of 16

2.4

2.08

0.00012

CL:24346

Adenylate cyclase activating pathway, and G-protein alpha subunit, group S

2 of 7

2.58

1.25

0.0053

CL:24684

Mixed, incl. Protein kinase inhibitor, and Negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

2 of 13

2.31

1.0

0.0141

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05032

Morphine addiction

8 of 69

2.19

5.9

2.31e-14

map04728

Dopaminergic synapse

8 of 103

2.01

5.03

2.40e-13

map04926

Relaxin signaling pathway

7 of 111

1.92

4.06

6.93e-11

map04724

Glutamatergic synapse

6 of 94

1.93

3.59

2.75e-09

map04062

Chemokine signaling pathway

7 of 154

1.78

3.45

4.76e-10

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-456926

Thrombin signalling through proteinase activated receptors (PARs)

5 of 28

2.37

4.11

6.48e-09

MAP-418555

G alpha (s) signalling events

7 of 109

1.93

3.89

2.93e-10

MAP-111885

Opioid Signalling

6 of 71

2.05

3.79

3.28e-09

MAP-381676

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

4 of 29

2.26

2.92

1.66e-06

MAP-432040

Vasopressin regulates renal water homeostasis via Aquaporins

4 of 31

2.23

2.88

1.86e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

4 of 8

2.82

3.7

1.39e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00339

Arrestin (or S-antigen), N-terminal domain

2 of 7

2.58

0.82

0.0326

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017864

Arrestin, conserved site

2 of 2

3.12

1.03

0.0142

IPR014753

Arrestin, N-terminal

2 of 2

3.12

1.03

0.0142

IPR000698

Arrestin

2 of 2

3.12

1.03

0.0142

IPR000367

G-protein alpha subunit, group S

2 of 2

3.12

1.03

0.0142

IPR011022

Arrestin C-terminal-like domain

2 of 6

2.65

1.02

0.0142

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00275

G protein alpha subunit

2 of 11

2.38

0.86

0.0262

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