STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1084 aa)    
Predicted Functional Partners:
PDGFB
Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.
   
 0.997
PDGFC
Platelet-derived growth factor C; Belongs to the PDGF/VEGF growth factor family.
    
 0.991
ENSEEUP00000000539
annotation not available
   
0.976
PDGFD
Platelet-derived growth factor D.
    
 0.970
ENSEEUP00000007255
annotation not available
    
 0.970
VEGFB
Vascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family.
    
 0.956
EGFR
Receptor protein-tyrosine kinase.
   
 0.953
FGF10
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
   
 0.948
ENSEEUP00000008074
annotation not available
   
 0.948
FGF7
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
   
 0.947
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.