INTS11 protein (Erinaceus europaeus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

INTS11

Integrator complex subunit 11 isoform X1. (600 aa)

Predicted Functional Partners:

ENSEEUP00000004045

0.998

INTS5

0.998

INTS9

0.998

INTS6

0.998

INTS3

0.997

ENSEEUP00000003272

0.993

ENSEEUP00000010190

0.992

INTS13

0.989

INTS10

0.986

INTS8

0.984

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEUP00000003272	ENSEEUP00000004045	ENSEEUP00000003272	ENSEEUP00000004045	annotation not available	annotation not available	0.996
ENSEEUP00000003272	ENSEEUP00000010190	ENSEEUP00000003272	ENSEEUP00000010190	annotation not available	annotation not available	0.997
ENSEEUP00000003272	INTS10	ENSEEUP00000003272	ENSEEUP00000011993	annotation not available	Integrator complex subunit 10.	0.991
ENSEEUP00000003272	INTS11	ENSEEUP00000003272	ENSEEUP00000000747	annotation not available	Integrator complex subunit 11 isoform X1.	0.993
ENSEEUP00000003272	INTS13	ENSEEUP00000003272	ENSEEUP00000004557	annotation not available	Protein asunder homolog.	0.982
ENSEEUP00000003272	INTS3	ENSEEUP00000003272	ENSEEUP00000004278	annotation not available	Integrator complex subunit 3.	0.997
ENSEEUP00000003272	INTS5	ENSEEUP00000003272	ENSEEUP00000009051	annotation not available	Integrator complex subunit 5.	0.998
ENSEEUP00000003272	INTS6	ENSEEUP00000003272	ENSEEUP00000011474	annotation not available	Integrator complex subunit 6 isoform X1.	0.998
ENSEEUP00000003272	INTS8	ENSEEUP00000003272	ENSEEUP00000001808	annotation not available	Integrator complex subunit 8.	0.997
ENSEEUP00000003272	INTS9	ENSEEUP00000003272	ENSEEUP00000010015	annotation not available	Integrator complex subunit 9.	0.988
ENSEEUP00000004045	ENSEEUP00000003272	ENSEEUP00000004045	ENSEEUP00000003272	annotation not available	annotation not available	0.996
ENSEEUP00000004045	ENSEEUP00000010190	ENSEEUP00000004045	ENSEEUP00000010190	annotation not available	annotation not available	0.997
ENSEEUP00000004045	INTS10	ENSEEUP00000004045	ENSEEUP00000011993	annotation not available	Integrator complex subunit 10.	0.983
ENSEEUP00000004045	INTS11	ENSEEUP00000004045	ENSEEUP00000000747	annotation not available	Integrator complex subunit 11 isoform X1.	0.998
ENSEEUP00000004045	INTS13	ENSEEUP00000004045	ENSEEUP00000004557	annotation not available	Protein asunder homolog.	0.981
ENSEEUP00000004045	INTS3	ENSEEUP00000004045	ENSEEUP00000004278	annotation not available	Integrator complex subunit 3.	0.998
ENSEEUP00000004045	INTS5	ENSEEUP00000004045	ENSEEUP00000009051	annotation not available	Integrator complex subunit 5.	0.998
ENSEEUP00000004045	INTS6	ENSEEUP00000004045	ENSEEUP00000011474	annotation not available	Integrator complex subunit 6 isoform X1.	0.998
ENSEEUP00000004045	INTS8	ENSEEUP00000004045	ENSEEUP00000001808	annotation not available	Integrator complex subunit 8.	0.987
ENSEEUP00000004045	INTS9	ENSEEUP00000004045	ENSEEUP00000010015	annotation not available	Integrator complex subunit 9.	0.999

page 1 of 6

Network Stats

number of nodes:

10

number of edges:

19

average node degree:

3.8

avg. local clustering coefficient:

0.894

expected number of edges:

11

PPI enrichment p-value:

0.0162

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0002031

G protein-coupled receptor internalization

3 of 6

2.82

2.11

0.00014

GO:0050909

Sensory perception of taste

3 of 27

2.17

1.55

0.0011

GO:0007200

Phospholipase C-activating G protein-coupled receptor signaling pathway

3 of 36

2.04

1.39

0.0020

GO:0007606

Sensory perception of chemical stimulus

6 of 410

1.29

1.25

0.00024

GO:0007191

Adenylate cyclase-activating dopamine receptor signaling pathway

2 of 5

2.73

1.22

0.0062

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001664

G protein-coupled receptor binding

6 of 166

1.68

2.24

2.92e-06

GO:0031690

Adrenergic receptor binding

2 of 9

2.47

0.88

0.0251

GO:0031683

G-protein beta/gamma-subunit complex binding

2 of 12

2.34

0.87

0.0254

GO:0071855

Neuropeptide receptor binding

2 of 16

2.22

0.79

0.0355

GO:0003924

GTPase activity

4 of 214

1.39

0.78

0.0199

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

5 of 26

2.41

3.91

2.04e-08

GO:0042995

Cell projection

8 of 1389

0.88

0.81

0.00016

GO:0120025

Plasma membrane bounded cell projection

7 of 1332

0.84

0.67

0.0017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:24323

Mixed, incl. Activation of GABAB receptors, and Amine ligand-binding receptors

5 of 53

2.1

2.86

1.18e-06

CL:24314

GPCR ligand binding, and G-protein mediated events

6 of 149

1.73

2.43

1.18e-06

CL:24328

Activation of GABAB receptors, and Dopamine receptor family

3 of 16

2.4

2.08

0.00012

CL:24346

Adenylate cyclase activating pathway, and G-protein alpha subunit, group S

2 of 7

2.58

1.25

0.0053

CL:24684

Mixed, incl. Protein kinase inhibitor, and Negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

2 of 13

2.31

1.0

0.0141

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05032

Morphine addiction

8 of 69

2.19

5.9

2.31e-14

map04728

Dopaminergic synapse

8 of 103

2.01

5.03

2.40e-13

map04926

Relaxin signaling pathway

7 of 111

1.92

4.06

6.93e-11

map04724

Glutamatergic synapse

6 of 94

1.93

3.59

2.75e-09

map04062

Chemokine signaling pathway

7 of 154

1.78

3.45

4.76e-10

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-456926

Thrombin signalling through proteinase activated receptors (PARs)

5 of 28

2.37

4.11

6.48e-09

MAP-418555

G alpha (s) signalling events

7 of 109

1.93

3.89

2.93e-10

MAP-111885

Opioid Signalling

6 of 71

2.05

3.79

3.28e-09

MAP-381676

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

4 of 29

2.26

2.92

1.66e-06

MAP-432040

Vasopressin regulates renal water homeostasis via Aquaporins

4 of 31

2.23

2.88

1.86e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

4 of 8

2.82

3.7

1.39e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00339

Arrestin (or S-antigen), N-terminal domain

2 of 7

2.58

0.82

0.0326

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017864

Arrestin, conserved site

2 of 2

3.12

1.03

0.0142

IPR014753

Arrestin, N-terminal

2 of 2

3.12

1.03

0.0142

IPR000698

Arrestin

2 of 2

3.12

1.03

0.0142

IPR000367

G-protein alpha subunit, group S

2 of 2

3.12

1.03

0.0142

IPR011022

Arrestin C-terminal-like domain

2 of 6

2.65

1.02

0.0142

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00275

G protein alpha subunit

2 of 11

2.38

0.86

0.0262

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (26%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About