ENSEEUP00000001536 protein (Erinaceus europaeus)

Nodes:

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second shell of interactors

Node Content

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

ENSEEUP00000001536

annotation not available (681 aa)

Predicted Functional Partners:

MTR

0.994

ENSEEUP00000008585

0.986

BHMT

0.986

SHMT2

0.958

MAT1A

0.949

MAT2A

0.948

MTHFD1

0.945

GLDC

0.940

GART

0.935

TYMS

0.934

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BHMT	ENSEEUP00000001536	ENSEEUP00000010899	ENSEEUP00000001536	Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism.	annotation not available	0.986
BHMT	ENSEEUP00000008585	ENSEEUP00000010899	ENSEEUP00000008585	Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism.	annotation not available	0.960
BHMT	GART	ENSEEUP00000010899	ENSEEUP00000000283	Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism.	annotation not available	0.918
BHMT	GLDC	ENSEEUP00000010899	ENSEEUP00000009036	Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism.	Glycine decarboxylase.	0.858
BHMT	MAT1A	ENSEEUP00000010899	ENSEEUP00000008067	Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism.	Methionine adenosyltransferase 1A.	0.971
BHMT	MAT2A	ENSEEUP00000010899	ENSEEUP00000002042	Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.933
BHMT	MTHFD1	ENSEEUP00000010899	ENSEEUP00000002077	Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism.	C-1-tetrahydrofolate synthase, cytoplasmic.	0.852
BHMT	MTR	ENSEEUP00000010899	ENSEEUP00000011124	Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism.	Methionine synthase-like.	0.926
BHMT	SHMT2	ENSEEUP00000010899	ENSEEUP00000014179	Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.781
BHMT	TYMS	ENSEEUP00000010899	ENSEEUP00000008242	Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism.	Thymidylate synthase.	0.785
ENSEEUP00000001536	BHMT	ENSEEUP00000001536	ENSEEUP00000010899	annotation not available	Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism.	0.986
ENSEEUP00000001536	ENSEEUP00000008585	ENSEEUP00000001536	ENSEEUP00000008585	annotation not available	annotation not available	0.986
ENSEEUP00000001536	GART	ENSEEUP00000001536	ENSEEUP00000000283	annotation not available	annotation not available	0.935
ENSEEUP00000001536	GLDC	ENSEEUP00000001536	ENSEEUP00000009036	annotation not available	Glycine decarboxylase.	0.940
ENSEEUP00000001536	MAT1A	ENSEEUP00000001536	ENSEEUP00000008067	annotation not available	Methionine adenosyltransferase 1A.	0.949
ENSEEUP00000001536	MAT2A	ENSEEUP00000001536	ENSEEUP00000002042	annotation not available	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.948
ENSEEUP00000001536	MTHFD1	ENSEEUP00000001536	ENSEEUP00000002077	annotation not available	C-1-tetrahydrofolate synthase, cytoplasmic.	0.945
ENSEEUP00000001536	MTR	ENSEEUP00000001536	ENSEEUP00000011124	annotation not available	Methionine synthase-like.	0.994
ENSEEUP00000001536	SHMT2	ENSEEUP00000001536	ENSEEUP00000014179	annotation not available	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.958
ENSEEUP00000001536	TYMS	ENSEEUP00000001536	ENSEEUP00000008242	annotation not available	Thymidylate synthase.	0.934

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.813

expected number of edges:

10

PPI enrichment p-value:

0.0158

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016444

Somatic cell DNA recombination

3 of 3

3.31

3.17

1.89e-06

GO:0070131

Positive regulation of mitochondrial translation

3 of 6

3.01

3.05

2.79e-06

GO:0007004

Telomere maintenance via telomerase

3 of 11

2.74

2.81

6.39e-06

GO:0006310

DNA recombination

6 of 202

1.78

2.64

4.50e-07

GO:0051321

Meiotic cell cycle

5 of 129

1.9

2.58

1.89e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043047

Single-stranded telomeric DNA binding

3 of 7

2.94

2.8

7.85e-06

GO:0008408

3-5 exonuclease activity

4 of 41

2.3

2.65

6.90e-06

GO:0000175

3-5-exoribonuclease activity

3 of 17

2.56

2.47

2.48e-05

GO:0003684

Damaged DNA binding

3 of 31

2.29

2.15

7.78e-05

GO:0003676

Nucleic acid binding

9 of 2305

0.9

1.78e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005662

DNA replication factor A complex

3 of 4

3.18

3.09

2.48e-06

GO:0043596

Nuclear replication fork

4 of 44

2.27

2.85

2.48e-06

GO:0000781

Chromosome, telomeric region

3 of 46

2.12

1.98

0.00013

GO:0000794

Condensed nuclear chromosome

2 of 23

2.25

1.34

0.0031

GO:0005634

Nucleus

9 of 3364

0.74

0.65

0.00013

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12858

HDR through Single Strand Annealing (SSA), and DNA damage sensor activity

7 of 42

2.53

6.43

1.08e-13

CL:12864

HDR through Single Strand Annealing (SSA), and Checkpoint clamp complex

5 of 17

2.78

5.42

5.55e-11

CL:12865

Mixed, incl. Checkpoint clamp complex, and FATC domain

3 of 12

2.71

2.88

4.53e-06

CL:12888

RecQ family helicase-topoisomerase III complex, and DNA replication factor A complex

2 of 5

2.91

1.82

0.00050

CL:12929

Mixed, incl. DNA topological change, and RecQ mediated genome instability protein 1, N-terminal

2 of 6

2.83

1.76

0.00063

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

4 of 132

1.79

1.92

6.09e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5685938

HDR through Single Strand Annealing (SSA)

7 of 42

2.53

6.86

1.16e-14

MAP-5693567

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

9 of 119

2.19

6.54

2.45e-16

MAP-5693538

Homology Directed Repair

9 of 131

2.15

6.36

2.81e-16

MAP-69473

G2/M DNA damage checkpoint

7 of 59

2.38

6.2

8.37e-14

MAP-6804756

Regulation of TP53 Activity through Phosphorylation

7 of 60

2.38

6.18

8.37e-14

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043596

Nuclear replication fork

5 of 28

2.56

4.48

2.24e-09

GOCC:0005662

DNA replication factor A complex

3 of 5

3.09

3.19

1.59e-06

GOCC:0031298

Replication fork protection complex

2 of 3

3.13

2.06

0.00019

GOCC:0043227

Membrane-bounded organelle

11 of 4151

0.73

0.71

2.17e-06

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 3677

0.74

0.69

2.17e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16900

Replication protein A OB domain

2 of 2

3.31

1.6

0.0013

PF04057

Replication factor-A protein 1, N-terminal domain

2 of 2

3.31

1.6

0.0013

PF01336

OB-fold nucleic acid binding domain

2 of 8

2.71

1.36

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002562

3-5 exonuclease domain

3 of 6

3.01

2.57

2.11e-05

IPR031657

Replication protein A, OB domain

2 of 2

3.31

1.51

0.0019

IPR007199

Replication factor-A protein 1, N-terminal

2 of 2

3.31

1.51

0.0019

IPR004365

OB-fold nucleic acid binding domain, AA-tRNA synthetase-type

2 of 8

2.71

1.19

0.0070

IPR012337

Ribonuclease H-like superfamily

3 of 108

1.75

0.99

0.0108

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00474

3-5 exonuclease

2 of 3

3.13

1.75

0.00069

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